Introduction Magnetization transfer ratio (MTR) magnetic resonance (MR) imaging is a promising technique for measuring in vivo demyelination and remyelination, providing a more direct measurement of activity in diseases like multiple sclerosis (MS). Incorporation of MTR in multicentre imaging protocols is feasible using stock sequences and MT pulses. However, such MTR values are sequence and sc...

BACKGROUND AND PURPOSE To determine whether occult disease fluctuates with macroscopic lesions during the natural history of multiple sclerosis (MS) and whether therapeutic interventions affect occult disease, we performed serial monthly magnetization transfer (MT) imaging in patients with relapsing-remitting MS in a crossover trial with interferon beta-lb. METHODS Serial whole-brain magnetiz...

The aim of the study was to assess the prevalence, the distribution and the impact on disability of grey matter (GM) pathology in early multiple sclerosis. Eighty-eight patients with a clinically isolated syndrome with a high risk developing multiple sclerosis were included in the study. Forty-four healthy controls constituted the normative population. An optimized statistical mapping analysis ...

INTRODUCTION Interindividual variations in regional structural properties covary across the brain, thus forming networks that change as a result of aging and accompanying neurological conditions. The alterations of superficial white matter (SWM) in Alzheimer's disease (AD) are of special interest, since they follow the AD-specific pattern characterized by the strongest neurodegeneration of the ...

OBJECTIVE To evaluate multimodal MRI of the spinal cord in predicting disease progression and one-year clinical status in amyotrophic lateral sclerosis (ALS) patients. MATERIALS AND METHODS After a first MRI (MRI1), 29 ALS patients were clinically followed during 12 months; 14/29 patients underwent a second MRI (MRI2) at 11±3 months. Cross-sectional area (CSA) that has been shown to be a mark...

Magnetization transfer (MT) and T(1) and T(2) relaxation of normal, trypsinized, and interleukin-1beta (IL-1beta)-treated cartilage were measured in the absence and presence of Gd-DTPA(2-). Without the addition of Gd-DTPA(2-), neither T(1) nor T(2) showed any significant change with cartilage damage. However, with Gd-DTPA(2-), trypsinized cartilage exhibited substantially shorter T(1) than norm...

s | 67 tissue, to identify biophysical alterations, which are represented by a magnetization transfer ratio (MTR). Whole brain voxelbased analysis was used to compare MTR across groups controlling for age and gender, thresholded at p < 0.05 (corrected) for a minimum cluster size of 132 voxels. Moreover, we conducted correlation analyses between the average regional values in affected regions wi...

The growth of white matter during human adolescence shows a striking sexual dimorphism; the volume of white matter increases with age slightly in girls and steeply in boys. Here, we provide evidence supporting the role of androgen receptor (AR) in mediating the effect of testosterone on white matter. In a large sample of typically developing adolescents (n = 408, 204 males), we used magnetic re...

Human visual cortical fields (VCFs) vary in size and anatomical location across individual subjects. Here, we used functional magnetic resonance imaging (fMRI) with retinotopic stimulation to identify VCFs on the cortical surface. We found that aligning and averaging VCF activations across the two hemispheres provided clear delineation of multiple retinotopic fields in visual cortex. The result...

Introduction The ability of tracking peripheral nerves in foot could be of great benefit for a number of clinical and research applications, which include traumas, diabetes and infections. Previous approaches to nerve tracking have employed diffusion tensor imaging (DTI, [1, 2]), which is a well established method of fiber tracking in the central nervous system. In the peripheral nervous system...