Magnetic mesoporous silica (MMS) nanoparticles with controllable magnetization have been synthesized by encapsulating Fe3O4 nanoparticles in a mesoporous silica matrix. The structure, magnetic heating capacity and drug delivery ability of MMS nanoparticles were evaluated. The results showed that MMS nanoparticles had an average particle size of 150 nm and showed low cytotoxicity and efficient c...

PURPOSE To develop and validate a computational model that simulates (1) tissue heating with high intensity focused ultrasound (HIFU), and (2) resulting hyperthermia-mediated drug delivery from temperature-sensitive liposomes (TSL). MATERIALS AND METHODS HIFU heating in tissue was simulated using a heat transfer model based on the bioheat equation, including heat-induced cessation of perfusio...

Introduction: Gd (III) ion has been known to be the best metal ion in the periodic table that can be used as a T1 MRI contrast agent. Gadolinium have 7 unpaired electrons and these electrons can make magnetic area. No other metal ions possess unpaired electron more than this. CAs based on the element Gd are classified as “positive”, by opposition to “negative” CAs. Nowadays, G...

To evaluate the effect of thermoseed inductive heating on mammary orthotopic transplantation tumors and immunologic function in rats. Walker-256 tumor cells were inoculated subcutaneously into the mammary glands of Wistar rats. Rats were allocated to five treatment groups as follows: i) C group (control group); ii) M group (magnetic field group); iii) T group (thermoseed control group); iv) H1 ...

The inefficiency and the low success rates of surgical resection and side effects of chemotherapy used in the treatment of hepatocellular carcinoma have elicited substantial research interest in alternative methods for treatment. Here we report the use of magnetic-dielectric composite of Chromium doped Iron Oxide (Cr0.2Fe1.8O3) – Polyvinylidene Fluoride (PVDF) for the hyperthermia treatment of ...

Since magnetic particles have unique features, the development of a variety of medical applications has been possible. The most unique feature of magnetic particles is their reaction to a magnetic force, and this feature has been utilized in applications such as drug targeting and bioseparation including cell sorting. Recently, magnetic nanoparticles have attracted attention because of their po...

Personalized Medicine In article 2203120 by Daniele De Pasquale, Carlotta Pucci, Gianni Ciofani, and co-workers, patient-derived cancer cell membrane-coated magnetic/lipid nanovectors allow for a precise personalized targeting against glioblastoma multiforme cells. The combination of magnetic hyperthermia chemotherapy, the latter selected based on patients' response, improve antitumor efficacy,...

Magnetic iron oxide nanoparticles were obtained for the first time via green chemistry approach, starting from two aqueous extracts of wormwood (Artemisia absinthium L.), both leaf and stems. In order to obtain magnetic suitable medical purposes, more precisely with hyperthermia inducing features, a synthesis reaction was conducted, at room temperature (25 °C) 80 °C, formulations precipitation ...

We undertook a study of the anti-tumour effects of hyperthermia, delivered via magnetite cationic liposomes (MCLs), on local tumours and lung metastases in a mouse model of osteosarcoma. MCLs were injected into subcutaneous osteosarcomas (LM8) and subjected to an alternating magnetic field which induced a heating effect in MCLs. A control group of mice with tumours received MCLs but were not ex...