Overexpression of the BltD gene in Bacillus subtilis causes acetylation of the polyamines spermidine and spermine. BltD is co-regulated with another gene, Blt, which encodes a multidrug export protein whose overexpression facilitates spermidine export [Woolridge, Vazquez-Laslop, Markham, Chevalier, Gerner and Neyfakh (1997) J. Biol. Chem. 272, 8864-8866]. Here we show that BltD acetylates both ...

BACKGROUND/AIMS Endoplasmic reticulum stress (ERS) plays an important role in the progression of acute myocardial infarction (AMI), in part by mediating apoptosis. Polyamines, including putrescine, spermidine, and spermine, are polycations with anti-oxidative, anti-aging, and cell growth-promoting activities. This study aimed to determine the mechanisms by which spermine protects against ERS-in...

In this paper, cubic nickel oxide nanoparticles were successfully prepared by solid-state thermal decomposition of nickel(II) macrocyclic Schiff-base complex at 450°C for 3 h without employing toxic solvent or surfactant and complicated equipment. nickel(II) macrocyclic Schiff-base complex was synthesized by the reaction of 1,2-bis(2-formyl-3-methoxyphenyl)propane, NiCl2•6H2O and 1,3-phenylened...

In this paper, cubic nickel oxide nanoparticles were successfully prepared by solid-state thermal decomposition of nickel(II) macrocyclic Schiff-base complex at 450°C for 3 h without employing toxic solvent or surfactant and complicated equipment. nickel(II) macrocyclic Schiff-base complex was synthesized by the reaction of 1,2-bis(2-formyl-3-methoxyphenyl)propane, NiCl2•6H2O and 1,3-phenylened...

Macrocyclic peptides can interfere with challenging biomolecular targets including protein-protein interactions. Whereas there are various approaches that facilitate the identification of peptide-derived ligands, their evolution into higher affinity binders remains a major hurdle. We report a virtual screen based on molecular docking that allows the affinity maturation of macrocyclic peptides t...

macrocyclic heterobinuclear zn(ii)–cu(ii) complexes with phenol based dicompartmental ligands possessing contiguous hexa- and penta-coordination sites were prepared by a stepwise procedure. the ligands include similar n4o2 and dissimilar n(imine)3o2 and n(amine)3o2 coordination sites sharing two phenolic oxygen atoms. the six-coordination site comprises two pyridyl pendant arms on the amine nit...

Inhibition of histone deacetylase (HDAC) function is a validated therapeutic strategy for cancer treatment. Of the several structurally distinct small molecule histone deacetylase inhibitors (HDACi) reported, macrocyclic depsipeptides possess the most complex cap groups and have demonstrated excellent HDAC inhibition potency and isoform selectivity. Unfortunately, the development of macrocyclic...

This research explores the first design and synthesis of macrocyclic peptide aldehydes as potent inhibitors of the 20S proteasome. Two novel macrocyclic peptide aldehydes based on the ring-size of the macrocyclic natural product TMC-95 were prepared and evaluated as inhibitors of the 20S proteasome. Both compounds inhibited in the low nanomolar range and proved to be selective for the proteasom...

A series of 18-membered macrocyclic complexes of metal Ni(II) of the type [M(H2Cy )] have been synthesized and characterized on the basis of spectral, magnetic and conductivity studies. The macrocyclic ligands H 4 Cy1-4 (Fig. 1) are tetrabasic having four imido hydrogen but behave in a dibasic manner. Out of eight nitrogens, four imido and four imino, ligands utilize four imido nitrogens for sq...

the macrocyclic ligands 2,3,5,6-bis{3’-bromo-5’-tert-butyl benzo-5-phenyl benzo} 12c3 (l1), 2,3,5,6-bis{3’-bromo-5’-tert butyl-benzo-5’-phenyl-benzo}15c4 (l2), 2,3,5,6-bis{3’-bromo-5’-tert butyl-benzo-5’-phenyl-benzo}18c5 (l3) have been synthesized and their alkaline metal compounds with naclo4∙h2o and kclo4  have been prepared. chemical formulas of all compounds have been characterized by usin...