Atopic dermatitis (AD) is considered associated with microbial dysbiosis. Dupilumab effective in improving AD, along restoring the skin bacterial microbiome, but its effect on mycobiome have not been investigated. In this prospective study, we aim to study of dupilumab fungal microbiome patients AD. Eight adult moderate severe AD were enrolled. All received monotherapy 300 mg every other week, ...

Cissampelos sympodialis Eichl is a plant from the Northeast and Southeast of Brazil. Its root infusion is popularly used for treatment of inflammatory and allergic diseases. We investigated whether warifteine, its main alkaloid, would have anti-inflammatory effect due to a blockage of neutrophil function. In vivo warifteine treatment inhibited casein-induced neutrophil migration to the peritone...

BACKGROUND The Malassezia genus includes mainly lipophilic yeasts belonging to the cutaneous microbiota of man and other mammals. Some Malassezia species have been associated with various dermatological diseases. The factors permitting the transformation of yeasts of the Malassezia genus from a commensal organism to a pathogenic agent are still little known but the production of various enzymes...

Given a model M and a temporal logic formula φ[?], where ? is a placeholder, the query checking problem, as defined for the case of CTL by Chan in 2000, is to find the strongest propositional formula f such that M |= φ[? ← f ]. The motivation for solving this problem is, among other things, to get insight on the model. We consider various objectives to the LTL query-checking problem, and study ...

Waiting in long queue is undesirable due to which in some practical situations customers become impatient and leave the system. In such cases providing additional servers can reduce long queue. This investigation deals with multi-server queueing system with additional servers and discouragement. The customers arrive in poisson fashion and are served exponentially by a pool of permanent and addi...