BACKGROUND Bortezomib has been successfully used in the treatment of multiple myeloma and has been proposed as a potential treatment for chronic lymphocytic leukemia. In this study we investigated the mechanism by which bortezomib induces apoptosis in chronic lymphocytic leukemia cells. DESIGN AND METHODS Using western blot analysis, we monitored the regulation of BCL2 family members, protein...

OBJECTIVES Lymphocytic prolactin (PRL) gene expression is detected in the majority of the immune cells and it is not known if this source contributes to hyperprolactinemia in systemic lupus erythematosus (SLE). We have therefore evaluated lymphocytic PRL secretion and gene expression in SLE and healthy controls. METHODS Thirty SLE patients (ACR criteria) and 10 controls were selected for the ...

BACKGROUND B-cell chronic lymphocytic leukemia is a clinically heterogeneous disease; some patients rapidly progress and die within a few years of diagnosis, whereas others have a long life expectancy with minimal or no treatment. Telomere length and telomerase levels have been proposed as prognostic factors; however, very few cases have been characterized for both parameters and no study has a...

BACKGROUND The aims of the present study were to ascertain the activation status of Akt in the primary cells of chronic lymphocytic leukemia and to investigate the effects of specific Akt inhibition on chronic lymphocytic leukemia-cell survival. DESIGN AND METHODS Anti-phospho-Akt (Ser473 or Thr308) antibodies and western blotting were used to establish the activation status of Akt. The effec...

Background: Leukemia is one of the major causes of mortality and disability and the seventh most prevalent cancer worldwide. It has various effects on different aspects of physical, psychological, reproductive, social, and economic performance of human life. This study compared the quality of life of patients with different types of leukemia hospitalized in Ayatollah Khansari Hospital in Arak- ...

the human leukocyte antigen g (hla-g) molecule exhibits limited tissue distribution, low polymorphism and alternative splicings that generate seven hla-g isoforms. hla-g exerts multiple immunoregulatory functions. recent studies indicate an ectopic up-regulation in tumor cells that may favor their escape from anti-tumor immune responses. this study it is an effort to clarify the presence of hla...

Lymphocytic gastritis is a histopathological entity characterised by the accumulation of small lymphocytes in the surface and foveolar epithelium. In order to investigate the correlation between endoscopy and histology in this condition, 192 observations selected on the basis of a presumed diagnosis of erosive or varioliform gastritis were reviewed. Ninety two instances corresponded to lymphocy...

Ataxia telangiectasia patients, with constitutional bi-allelic ATM mutations, have a marked risk of lymphoid tumors and ATM mutation carriers have a smaller risk of cancer. Sporadic ATM mutations occur in 10-20% of chronic lymphocytic leukemia and are often associated with chromosome 11q deletions which cause loss of an ATM allele. The role of constitutional ATM mutations in the pathogenesis of...