A number of effective treatments are available for patients with hairy cell leukemia (HCL). 2-Chlorodeoxyadenosine (2-CdA) induces more than 80% complete responses, but is associated with profound suppression of CD4+ lymphocyte counts. However, the duration of each is uncertain. We have analyzed a previously reported cohort of 40 patients who had responded to 2-CdA. Eight patients (20%) have re...

BACKGROUND Cytomegalovirus retinitis is a common AIDS-associated illness, leading to blindness in up to 30% of patients. This study was to investigate the prevalence and clinical management of the cytomegalovirus retinitis associated with AIDS in a large municipality of China. METHODS Clinical and laboratory data from 23 cytomegalovirus retinitis patients (35 eyes) out of 303 hospitalized AID...

Immune enhancement through the use of natural products is a potentially valuable therapeutic modality in HIV-infected people, especially those who are not good candidates for aggressive ARV therapy. One such immune enhancement, a medicinal mushroom product from the United States, is Immune Assist 24/7. In this study the effect of Immune Assist 24/7, which is a naturally derived immune-modulatin...

OBJECTIVE To evaluate the safety and tolerability of subcutaneous (s.c.) cladribine therapy in patients with chronic progressive multiple sclerosis (CPMS), and to evaluate the effects on lymphocyte subsets. BACKGROUND Cladribine, a synthetic antineoplastic agent with immunosuppressive effects, may favourably affect the course of CPMS. However results of a previous reported clinical trial show...

Abstract We assessed the development of lymphopenia during concurrent chemoradiotherapy (CRT) using X-ray versus proton beams and impact on survival in patients with esophageal cancer. Among cancer who were administered CRT a curative intent at our institute from 2014 to 2018, 69 (15 receiving radiotherapy (XRT) 54 beam therapy [PBT]) underwent weekly blood testing treatment enrolled. The absol...

PURPOSE Predicting late effects in patients treated with radiation therapy by assessing in vitro radiation-induced CD4 and CD8 T-lymphocyte apoptosis can be useful in individualizing treatment. EXPERIMENTAL DESIGN In a prospective study, 399 curatively irradiated patients were tested using a rapid assay where fresh blood samples were in vitro irradiated with 8 Gy X-rays. Lymphocytes were coll...

OBJECTIVE The objective of the trial was to evaluate in a pilot setting the safety and efficacy of interleukin-2 (IL-2) therapy when used without concomitant antiretroviral therapy as a treatment for HIV infection. DESIGN AND SETTING This was a multicentre randomised three-arm trial conducted between September 1998 and March 2001 at three clinical centres in the United Kingdom. PARTICIPANTS...

despite many advances in the treatment of breast cancer, it is still the second most common cause of death in women in the united states. it has been shown that inflammation plays a major role in the treatment of these cancers and inflammatory factors enhance tumor growth, invasion, metastasis, and vascularization. in this study, we would like to analyze peripheral blood neutrophil-lymphocyte r...

Therapy with immune checkpoint inhibitors (ICIs) can lead to durable tumor control in patients various advanced stage malignancies. However, this is not the case for all patients, leading an ongoing search biomarkers predicting response and outcome ICI. The B T lymphocyte attenuator (BTLA) expressed on cells that was shown modulate therapeutic responses. Here, we evaluate circulating levels of ...