نتایج جستجو برای: lupus glomerulonephritis

تعداد نتایج: 53835  

2017
Asmaa S. Abu Maziad Jose Torrealba Mouin G. Seikaly Jared R. Hassler Allen R. Hendricks

Systemic lupus erythematosus (SLE) is an autoimmune disease characterized by development of autoantibodies to nuclear and cytoplasmic antigens. A small subset of SLE patients who had the typical clinical features of SLE was reported to show persistently negative antinuclear antibody tests. Our report describes a 5-year-old male who presented with histopathological findings suggestive of lupus n...

Journal: :Frontiers in bioscience : a journal and virtual library 2008
Onkar Kulkarni Hans-Joachim Anders

Lupus nephritis is a common solid organ manifestation of systemic lupus erythematosus (SLE). The disease is tightly linked to the production of autoantibodies and circulating immune complexes, i.e. immune complex glomerulonephritis. In this process chemokines mediate multiple biological effects, e.g. orchestrating proinflammatory microenvironments, the recruitment of immune cell subsets into th...

2013
Simon J. Freeley Angela Giorgini Calogero Tulone Reena J. Popat Catherine Horsfield Michael G. Robson

Systemic lupus erythematosus is an autoimmune disease with a high morbidity and nephritis is a common manifestation. Previous studies in murine lupus models have suggest a role for Toll-like receptor 2 and 4. We examined the role of these molecules in MRL lpr mice which is one of the most established and robust murine models. We compared disease parameters in Toll-like receptor 2 or Toll-like r...

Journal: :Journal of immunology 2013
Andrew L Rankin Nilufer Seth Sean Keegan Tatyana Andreyeva Tim A Cook Jason Edmonds Nagappan Mathialagan Micah J Benson Jameel Syed Yutian Zhan Stephen E Benoit Joy S Miyashiro Nancy Wood Shashi Mohan Elena Peeva Shashi K Ramaiah Dean Messing Bruce L Homer Kyri Dunussi-Joannopoulos Cheryl L Nickerson-Nutter Mark E Schnute John Douhan

Autoantibody production and immune complex deposition within the kidney promote renal disease in patients with lupus nephritis. Thus, therapeutics that inhibit these pathways may be efficacious in the treatment of systemic lupus erythematosus. Bruton's tyrosine kinase (BTK) is a critical signaling component of both BCR and FcR signaling. We sought to assess the efficacy of inhibiting BTK in the...

2014
Zhuo-Long Wang Xiao-Fang Luo Meng-Tao Li Dong Xu Shuang Zhou Hou-Zao Chen Na Gao Zhen Chen Ling-Ling Zhang Xiao-Feng Zeng

BACKGROUND Systemic lupus erythematosus (SLE) is a multisystemic autoimmune disease characterized by the production of autoantibodies. To date, no therapy has been found to satisfactorily treat SLE. SIRT1 deficiency results in the development of an autoimmune syndrome in mice, including a high titer of anti-nuclear antibody in serum, immunoglobulin deposition in the kidney, and immune complex g...

Journal: :Reumatologia clinica 2009
Juan M Miranda Luis J Jara Concepción Calleja Miguel A Saavedra Reyna M Bustamante Ulises Angeles

UNLABELLED Antiphospholipid syndrome nephropathy (APSN) is now a well recognized vaso-occlusive renal lesion associated with acute thrombosis and chronic arterial and arteriolar lesions, leading to zones of cortical ischemic atrophy. Our objective was to evaluate the prevalence and clinical significance of APSN in patients with Systemic Lupus Erythematosus (SLE). METHODS Kidney biopsy specime...

2003
HUGH O. MCDEVITT

The F, hybrids of the autoimmune New Zealand Black (NZB) mice and the phenotypically normal New Zealand White (NZW) mouse strain, develop severe systemic autoimmune disease, more fulminant than that found in the parental NZB strain . These mice manifest several immune abnormalities including antibodies to nuclear antigens and subsequent development of a fatal, immune complex-mediated glomerulon...

Journal: :Clinical journal of the American Society of Nephrology : CJASN 2008
Daniel J Birmingham Brad H Rovin Ganesh Shidham Michael Bissell Haikady N Nagaraja Lee A Hebert

BACKGROUND AND OBJECTIVES Albuminuria is regarded a sensitive measure of progression of glomerular disease. This study was undertaken in patients who had systemic lupus erythematosus glomerulonephritis (n = 57) and were followed in the Ohio SLE Study to determine whether measuring albuminuria offered clinical advantages over that of total proteinuria. DESIGN, SETTING, PARTICIPANTS, & MEASUREM...

Journal: :Blood 1993
H Mizutani R W Engelman K Kinjoh Y Kurata S Ikehara R A Good

Male (NZW x BXSB)F1 (W/BF1) mice develop systemic autoimmunity involving autoantibodies, thrombocytopenia, lupus nephritis, and coronary vascular disease with myocardial infarction (CVD). To determine whether this murine lupus-associated CVD could be transferred to otherwise autoimmune-resistant (C57BL/6 x C3H/He)F1 (B6C3F1) mice via W/BF1 T-cell-depleted marrow (TCDM) transplants, or conversel...

Journal: :Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association 2011
Cornelia Bigler Helmut Hopfer Doris Danner Monica Schaller Michael J Mihatsch Marten Trendelenburg

BACKGROUND In systemic lupus erythematosus patients, a strong association between the occurrence of antibodies against complement C1q (anti-C1q) and lupus nephritis can be observed. However, the predictive value of anti-C1q titres for a renal flare remains to be determined. Increasing titres of anti-C1q before the occurrence of clinical apparent nephritis might not only serve as a clinical para...

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