the introduction of ex vivo lung perfusion (evlp) in the practice of lung transplantation has allowed the reconditioning of the marginal grafts and their conversion into transplantable grafts. in addition, evlp can provide a platform for the application of various preventive measures to decrease the incidence of post-transplant complications. while the toronto team targets the attenuation of th...

CLINICAL INTRODUCTION A 36-year-old woman with Down’s syndrome and spleen hypoplasia presented with a fever of 40°C lasting for 12 h. She had taken 1 mg prednisolone/day for mild graft-versus-host disease after allogeneic stem cell transplantation 4 years previously. Her BP was 91/44 mm Hg, HR 110 beats/min and RR 30 breaths/ min. Her heart sound, lung sound and skin appearance were unremarkabl...

The association between lung sound alterations and airways obstruction has long been recognized in clinical practice, but the precise pathophysiological mechanisms of this relationship have not been determined. Therefore, we examined the changes in lung sounds at well-defined levels of methacholine-induced airway narrowing in eight normal and nine asthmatic subjects with normal baseline lung fu...

The pressure-flow (P-Q) curve has been widely used in many studies to describe the effects of various factors on vascular hemodynamics. It is not clear, however, whether unilateral ischemia-reperfusion (IR) alters the P-Q curve of the rat lung. In this study, we developed an in vivo P-Q curve using the unilateral (left) rat lung before and after IR. Animals were divided into two groups: sham an...

Asthma is the most common chronic illness among children. The skills required to diagnose it make it an even greater concern. In this work, we present a child-friendly wearable device, which allows in-home diagnosis of asthma. The device acquires simultaneous measurements from multiple stethoscopes. The recordings are then sent to a specialist who uses assistive diagnosis algorithms that enable...

conclusion lesion depth from the pleural surface and the presence of emphysema were strongly correlated with the increasing incidence of pneumothorax after ct-guided pcnb. our results may be applicable for the risk management of pcnbs to reduce pneumothorax as a complication. background previous studies identifying risk factors for pneumothorax in percutaneous core needle lung biopsies reported...

BACKGROUND Crackles are very common abnormal breath sounds in the lung and can be used to diagnose pulmonary diseases. OBJECTIVE In this study, a method is proposed for the detection of adventitious transient sounds from normal breath sounds. METHODS This method automatically recognizes crackles based on the extraction and analysis of spectral information from digitally recorded lung sounds...