We have used the pig, a large natural host animal for influenza with many physiological similarities to humans, characterize αβ, γδ T cell and antibody (Ab) immune responses 2009 pandemic H1N1 virus infection. evaluated kinetic of infection associated response in inbred Babraham pigs identical MHC (Swine Leucocyte Antigen) compared them commercial outbred animals. High level nasal shedding cont...

Oxygen exposure in preterm infants has been associated with altered lung development and increased risk for respiratory viral infections later in life. Although the dose of oxygen sufficient to exert these changes in humans remains unknown, adult mice exposed to 100% oxygen between postnatal days 1-4 exhibit alveolar simplification and increased sensitivity to influenza virus infection. Additio...

COVID-19 is typically a respiratory or lung infection however the SARS-CoV-2 virus has been found to cause blood clots leading stroke. The World Stroke Organization reported 5% risk for an ischemic stroke in setting of

Our report discusses a patient diagnosed with PAN since 3 years ago. He presented with fever, chills and nonproductive cough. He was a long time receiver of immunosuppressant drugs for his underlying condition. Upon examination he was febrile, had cushingoid appearance and cackles in both lungs. Lung CT scan showed opacities in right upper lobe lung and multiple bilateral nodules and ground gla...

BACKGROUND Influenza virus infection causes significantly higher levels of morbidity and mortality in the elderly. Studies have shown that impaired immunity in the elderly contributes to the increased susceptibility to influenza virus infection, however, how aging affects the lung tissue damage and repair has not been completely elucidated. METHODS Aged (16-18 months old) and young (2-3 month...

BACKGROUND The intratracheal instillation of Pseudomonas aeruginosa entrapped in agar beads in the mouse lung leads to chronic lung infection in susceptible mouse strains. As the infection generates a strong inflammatory response with some lung edema, we tested if it could modulate the expression of genes involved in lung liquid clearance, such as the alpha, beta and gamma subunits of the epith...

Objective: To observe and analyse the positive effect of systematic nursing intervention on lung infection of ICU patients. Method: 68 cases of lung infection from patients who were accepted into ICU were selected randomly between April 2016 and November 2016. These 68 patients were divided into two groups including observation group and control group. Treat the observation group with systemati...

Neutrophilic airway inflammation in chronic lung infections caused by Pseudomonas aeruginosa (PA) is associated with T helper (Th)17 responses. Suppressor of cytokine signaling 3 (SOCS3) is the major negative modulator of Th17 function through the suppression of signal transducer and activator of transcription (STAT)3 activation. The aim of the present study was to investigate the expression of...

In a healthy individual, the lung contains few lymphoid cells. However, amplified immune responses, as exemplified during lung infection, can cause extensive tissue damage. We have previously demonstrated that one lung infection modulates the immunopathological outcome to a subsequent unrelated pathogen. Mimicking heterologous immunity may provide a means of enhancing both innate and acquired i...

BACKGROUND Surfactant protein D (SP-D) and Mannose Binding Lectin (MBL) are collectins that have opsonic and immunoregulatory functions, are found in lung fluid and interact with the human immunodeficiency virus (HIV). We compared collectin levels in lung fluid and serum from HIV infected and normal subjects to determine if alterations in lung collectin levels were associated with HIV infection...