Interdependence between airways and the lung parenchyma is thought to be a major mechanism preventing excessive airway narrowing during bronchoconstriction. Because the elastance of the lung increases during bronchoconstriction, the lung's tethering force could also increase, further attenuating bronchoconstriction. We hypothesized that the bulk (kappa) and shear moduli (mu) of the lung increas...

Introduction: According  to  the  latest  statistical  and  epidemiological  studies,  COPD  will  become  the  fourth  leading  cause  of  death  in  2030  worldwide.  Scientists  are  studying  on  methods  to  diagnose  COPD  in  the  patients  in  early  stages,  because  it  is  a  curable  and  preventable  disease  in  early  stages.  In  this  study,  evidences  of  hyperinflation  on  ...

Bronchiolitis is the most common lower respiratory tract infection among infants and young children [1]. Nowadays oxygenation and clinical assessment are used to decide on hospitalization. Jacob et al. recently explored the role of capnography upon arrival to the Emergency Department and concluded that endtidal carbon dioxide (EtCO2) does not predict neither hospital admission nor discharge eli...

Gillam, G. L., McNicol, K. N., and Williams, H. E. (1970). Archives of Disease in Childhood, 45, 789. Chest deformity, residual airways obstruction and hyperinflation, and growth in children with asthma. Part II: Significance of chronic chest deformity. Studies were made on 56 10-11-year-old asthmatic children with onset of symptoms before 3 years of age, frequent and persistent attacks, and ob...

AIM We investigated the therapeutic effects of aerobic training on lung mechanics, inflammation, morphometry and biological markers associated with inflammation, and endothelial cell damage, as well as cardiac function in a model of elastase-induced emphysema. METHODS Eighty-four BALB/c mice were randomly allocated to receive saline (control, C) or 0.1 IU porcine pancreatic elastase (emphysem...

In a retrospective study we investigated the accuracy of radiographic measurements of hyperinflation in distinguishing a sample of patients with a clinical diagnosis of pulmonary emphysema (n = 44) from a sample of age- and sex-matched control subjects (n = 39). The relationship of the hyperinflation parameters to pulmonary function test results (PFTs) and arterial blood gas measurements (ABGs)...

INTRODUCTION At present, COPD is known to be a systemic disease resulting from generalized inflammation which affects the function of many organs. Generalized inflammation is recognized from increased serum concentration of inflammatory cytokines. The aim of the present study was to investigate the influence of inflammatory process on the respiratory impairment in patients with stable chronic o...

Chronic obstructive pulmonary disease (COPD) is a progressive lung disease characterized by pathophysiological factors including airflow limitation, hyperinflation and reduced gas exchange. Treatment consists of lifestyle changes, lung rehabilitation and pharmacological therapies such as long acting beta-2-agonists (LABA) and long acting muscarinic antagonists (LAMA). More recently bronchoscopi...