نتایج جستجو برای: lung delivery

تعداد نتایج: 508290  

Journal: :Tuberculosis 2003
N Tsapis D Bennett K O'Driscoll K Shea M M Lipp K Fu R W Clarke D Deaver D Yamins J Wright C A Peloquin D A Weitz D A Edwards

Para-aminosalicylic acid (PAS), a tuberculostatic agent, was formulated into large porous particles for direct delivery into the lungs via inhalation. These particles possess optimized physical properties for deposition throughout the respiratory tract, a drug loading of 95% by weight and physical stability over 4 weeks at elevated temperatures. Upon insufflation in rats, PAS concentrations wer...

Journal: :Proceedings of the National Academy of Sciences of the United States of America 2015
Marcel Filoche Cheng-Feng Tai James B Grotberg

Surfactant replacement therapy (SRT) involves instillation of a liquid-surfactant mixture directly into the lung airway tree. It is widely successful for treating surfactant deficiency in premature neonates who develop neonatal respiratory distress syndrome (NRDS). However, when applied to adults with acute respiratory distress syndrome (ARDS), early successes were followed by failures. This un...

Journal: :مجله دانشگاه علوم پزشکی شهید صدوقی یزد 0
ابوالفضل برخورداری a barkhordari جان کلور j mcclure

introduction: the respiratory system is both a route of entry and exit for toxins and injurious agents, as well as being a target for chemical substances and pathogens. therefore, an understanding of the structure and function of the migratory cell populations of pulmonary tissues including alveolar macrophages is central in a number of important disease processes. this study aimed to identify ...

2014
Andrew R Martin Chris Jackson Ira M Katz Georges Caillibotte

BACKGROUND Nitric oxide (NO) is currently administered using devices that maintain constant inspired NO concentrations. Alternatively, devices that deliver a pulse of NO during the early phase of inspiration may have use in optimizing NO dosing efficiency and in extending application of NO to long-term use by ambulatory, spontaneously breathing patients. The extent to which the amount of NO del...

Journal: :iranian journal of allergy, asthma and immunology 0
marjan mosayebzadeh immunoregulation research center, shahed university, tehran, iran tooba ghazanfari immunoregulation research center, shahed university, tehran, iran alireza delshad department of anatomical sciences and pathology, faculty of medicine, shahed university, tehran, iran hassan akbari department of pathology, shahid beheshti university of medical sciences, tehran, iran

lung exposure to sulfur mustard (sm) results in pulmonary complications, which is the main cause of long-term disability and morbidity. up to now, the precise mechanisms of sm-induced lung complications has not been identified. the aim of this study was to evaluate apoptosis in the lung tissue of sm-exposed individuals. the study was performed on archived lung paraffin-embedded tissue specimens...

Journal: :avicenna journal of medical biotechnology 0

background: mehr-80 is a newly established adherent human large cell lung cancer cell line that has not been transfected until now. this study aims to define the optimal transfection conditions and effects of some critical elements for enhancing gene delivery to this cell line by utilizing different non-viral transfection procedures. methods: in the current study, calcium phosphate (cap), deae-...

2010
Cigdem Aydin Ahter D Sanlioglu Atil Bisgin Burcak Yoldas Levent Dertsiz Bahri Karacay Thomas S Griffith Salih Sanlioglu

Title: NF-kappaB targeting by way of IKK inhibition sensitizes lung cancer cells to adenovirus delivery of TRAIL

Journal: :Chest 1998
J H Wildhaber M J Hayden N D Dore S G Devadason P N LeSouëf

STUDY OBJECTIVES The aim of our study was to determine the in vitro delivery of salbutamol from a pressurized metered-dose inhaler (pMDI) containing hydrofluoroalkane (HFA) propellant through various delivery devices to four models of a pediatric lung. DESIGN To determine the effect of electrostatic charge, delivery of salbutamol was initially assessed with a multistage liquid impinger (MSLI)...

2013
Navin Kumar Verma Kieran Crosbie-Staunton Amro Satti Shane Gallagher Katie B Ryan Timothy Doody Colm McAtamney Ronan MacLoughlin Paul Galvin Conor S Burke Yuri Volkov Yurii K Gun’ko

BACKGROUND Aerosolized therapeutics hold great potential for effective treatment of various diseases including lung cancer. In this context, there is an urgent need to develop novel nanocarriers suitable for drug delivery by nebulization. To address this need, we synthesized and characterized a biocompatible drug delivery vehicle following surface coating of Fe3O4 magnetic nanoparticles (MNPs) ...

Journal: :Anesthesiology 2015
Mairead Hayes Claire Masterson James Devaney Frank Barry Steve Elliman Timothy O'Brien Daniel O'Toole Gerard F Curley John G Laffey

BACKGROUND Rodent mesenchymal stem/stromal cells (MSCs) enhance repair after ventilator-induced lung injury (VILI). We wished to determine the therapeutic potential of human MSCs (hMSCs) in repairing the rodent lung. METHODS In series 1, anesthetized rats underwent VILI (series 1A, n = 8 to 9 per group) or protective ventilation (series 1B, n = 4 per group). After VILI, they were randomized t...

نمودار تعداد نتایج جستجو در هر سال

با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید