This report describes a case of extensive diffuse bone marrow involvement with bilateral breast metastases from duodenal neuroendocrine tumor giving rise to a superscan-like appearance on somatostatin receptor-targeted (99m)Tc-hydrazinonicotinamide-TOC scintigraphy. The metastatic lesions demonstrated partial concordance with (18)F-FDG PET/CT findings, signifying varying tumor biology and heter...

We establish formulae for the Iwasawa invariants of Mazur–Tate elements of cuspidal eigenforms, generalizing known results in weight 2. Our first theorem deals with forms of “medium” weight, and our second deals with forms of small slope. We give examples illustrating the strange behavior which can occur in the high weight, high slope case.

Let O denote the ring of integers in a p-adic local field. Recall that O-modules are formal groups with an O-action such that the induced action on the Lie algebra is via scalars. In the paper this notion is generalised to finite flat group schemes. It is shown that the usual properties carry over. For example, Cartier duality holds with the multiplicative group replaced by the Lubin–Tate group...

I. Background material 1 A. Mumford-Tate groups and domains B. The structure theorem for global variations of Hodge structure C. Hodge groups and domains II. General context A. Algebro-geometric B. Representation theoretic C. Arithmetic III. Cyclic spaces and their enlargements A. General definitions and some properties B. Two examples C. Enlargements of cycle spaces IV. Penrose-Radon transform...

In his 1982 paper, Ogus defined a class of cycles in the de Rham cohomology of smooth proper varieties over number fields. This notion is a crystalline analogue of `-adic Tate cycles. In the case of abelian varieties, this class includes all the Hodge cycles by the work of Deligne, Ogus, and Blasius. Ogus predicted that such cycles coincide with Hodge cycles for abelian varieties. In this paper...

UNLABELLED Peptide receptor radionuclide therapy (PRRT) is a promising treatment for patients with neuroendocrine tumors, giving rise to improved survival. Dosimetric calculations in relation to PRRT have been concentrated to normal organ dosimetry in order to limit side effects. However, the relation between the absorbed dose to the tumor and treatment response has so far not been established....

Abstract Background Extravasation of radiopharmaceuticals used for vectorized internal radiotherapy can lead to severe tissue damage (van der Pol et al., Eur J Nucl Med Mol Imaging 44:1234–1243, 2017). Clinical management these extravasations requires the preliminary estimation dose distribution in extravasation area. Data are scarce regarding literature. This work presents a methodology estima...

Introduction: In Peptide Receptor Radionuclide Therapy (PRRT), the administration of radionuclide such as Lu-177 label with a pharmaceutical agent useful to destroy the lesion. The amount of Lu-177 radioactivity administered to the patients is still not standardize and generally not more than 7.4 GBq per session due to the patient’s safety issues. The first cycle of Lu-177 is a...