In the last decades, gain-scheduling control techniques have consolidated as an efficient answer to analysis and synthesis problems for non-linear systems. Among the approaches proposed in the literature, the linear parameter varying (LPV) and TakagiSugeno (TS) paradigms have proved to be successful in dealing with the different trials that the analyzer, or the designer, of a gain-scheduled con...

Using measured free fraction and 50% inhibitory concentration (IC50) values for the human immunodeficiency virus protease inhibitors lopinavir (LPV) and ritonavir (RTV) in tissue culture media with various protein concentrations ranging from 5 to 50%, we estimated serum-free IC50 values for each drug. The range of serum-free IC50 values (0.64 to 0.77 ng/ml for LPV and 3.0 to 5.0 ng/ml for RTV) ...

This paper addresses a discussion about Unknown Input Observers (UIO) for Linear Parameter Varying (LPV) systems designed classically by using the polytopic representation. It is shown that even if the rank conditions ensuring the existence of an UIO are satisfied, the design may fail, due to the polytopic representation of the LPV system. In this paper a new design approach is proposed via a m...

The paper describes the design of aeroservoelastic controllers using H1 and LPV control design techniques for a Body Freedom Flutter aircraft. The controllers are compared in the frequency and time domain The LPV controller does not achieve the level of performance of the individual H1 controllers, though the performance achieves the desired objectives. The similarities and difference between t...

The use of lopinavir/ritonavir (LPV/r) could be associated with testicular toxicity as a limiting factor. The present study evaluated the effects of melatonin (MT) and alpha lipoic (ALA) acid on LPV/r–induced testicular toxicity in male albino rats. Eighty five male albino rats used for this study were randomized into 6 groups (A-F). Rats in group A1 and A2 served as placebo and solvent control...

We have conducted an optical long-term monitoring survey of the majority of dwarf galaxies in the Local Group, with the Isaac Newton Telescope (INT), to identify the long period variable (LPV) stars. LPV stars vary on timescales of months to years, and reach the largest amplitudes of their brightness variations at optical wavelengths, due to the changing temperature. They trace stellar populati...

Introduction There is good evidence that all invasively ventilated patients should undergo lung-protective ventilation (LPV) [1,2]. As well as LPV, there is a strong evidence base for other routine interventions in the care of ventilated patients. We performed a one day snapshot audit and survey of attitudes towards invasive ventilation practice in intensive care units across the Severn (Bristo...

The missile autopilot was designed using linear parameter-varying (LPV) control techniques. The controller provides exponential stability guarantee and performance bound in terms of induced L2 norm for the missile plant. The systematic gain-scheduling approach is motivated by the recent development in LPV control theory and provides a well founded and systematic procedure for high performance m...

BACKGROUND Pharmacokinetic data for lopinavir in late pregnancy and in breastfeeding are limited, and no data for abacavir in breast milk are available. METHODS Women in the Mma Bana Study initiated HAART from 18 to 34 weeks of gestation. We determined trough plasma and whole breast milk concentrations of lopinavir (LPV), abacavir (ABC), nevirapine (NVP), lamivudine (3TC) and zidovudine (ZDV)...

OBJECTIVES South Africa's national antiretroviral (ARV) treatment program expanded in 2010 to include the nucleoside reverse transcriptase (RT) inhibitors (NRTI) tenofovir (TDF) for adults and abacavir (ABC) for children. We investigated the associated changes in genotypic drug resistance patterns in patients with first-line ARV treatment failure since the introduction of these drugs, and prote...