Renovascular hypertension is a potentially curable form of high blood pressure that is thought to be extremely rare among blacks. We demonstrate, however, that in a clinically selected population, the prevalence of renovascular hypertension is similar in blacks and whites. We prospectively evaluated 167 hypertensive subjects who had one or more clinical features known to be associated with reno...

Our previous studies support the hypothesis that activation of the renin-angiotensin system by renal ischemia elevates adenosine levels and that adenosine acts in a negative feedback loop to limit renin release and to mitigate some of the hypertension-producing effects of angiotensin II. To further test this hypothesis, we compared the time course of caffeine-induced increases in plasma renin a...

Supine plasma concentrations of epinephrine and norepinephrine were measured by a radioenzymatic method in 69 patients with essential hypertension and were compared with the levels found in 40 patients with hypertension resulting from chronic parenchymatous renal disease and in 18 normotensive controls. Mean plasma levels of epinephrine and norepinephrine were not statistically different in pri...

We have tested the steady-state predictions of the hypothesis that coarctation hypertension, if renin-mediated via total-renal underperfusion, will be characterized by a persistently abnormal renin/bodyfluid-volume relationship. In six inbred Labrador dogs with neonatally-induced thoracic aortic coarctation and in seven littermate controls, serial measurements of forelimb BP, plasma renin activ...

A 27-year-old woman with an adrenal tumor that produced renin and aldosterone, associated with hypertension and adrenogenital syndrome, is described. Severe hypertension, cardiomegaly, a low serum potassium level, clinical symptoms of adrenogenital syndrome, and a left upper abdominal tumor also were found. Endocrinologies! studies showed that plasma and urinary levels of sex steroid hormones s...

It is well known that the brain renin-angiotensin (RAS) system plays an essential role in the development of hypertension, mainly through the modulation of autonomic activities and vasopressin release. However, how the brain synthesizes angiotensin (Ang) II has been a debate for decades, largely due to the low renin activity. This paper first describes the expression of the vasoconstrictive arm...

1. When the renin-angiotensin system of rats had been suppressed by a high salt diet or by bilateral nephrectomy, large doses of angiotensin I1 antiserum were required to block the pressor action of exogenous angiotensin 11. Infusion of renin profoundly lowered the blocking requirement of such animals. 2. It is postulated that renin bound to blood vessels generates angiotensin locally which is ...

Severe low-renin hypertension has few known causes. Apparent mineralocorticoid excess (AME) is a genetic disorder that results in severe juvenile low-renin hypertension, hyporeninemia, hypoaldosteronemia, hypokalemic alkalosis, low birth weight, failure to thrive, poor growth, and in many cases nephrocalcinosis. In 1995, it was shown that mutations in the gene (HSD11B2) encoding the 11beta-hydr...

1. Haemodynamics, blood volume, plasma renin concentration and creatinine clearance were evaluated in 24 stable renal transplant recipients. 2. The mean cardiac index of the transplant recipients was not different from that of the normal subjects. 3. The transplant recipients comprised eight hypertensive and 16 normotensive patients. The mean cardiac index was the same in eight hypertensive and...