Characteristic features of Alzheimer's disease are memory loss, plaques resulting from abnormal processing of amyloid precursor protein (APP), and presence of neurofibrillary tangles and dystrophic neurites containing hyperphosphorylated tau. Currently, it is not known what links these abnormalities together. Cytoplasmic FMR1 interacting protein 2 (CYFIP2) has been suggested to regulate mRNA tr...

The secular evolution of the orbital angular momentum (OAM), the systemic mass (M = M1+M2) and the orbital period of 114 chromospherically active binaries (CABs) were investigated after determining the kinematical ages of the sub-samples which were set according to OAM bins. OAMs, systemic masses and orbital periods were shown to be decreasing by the kinematical ages. The first order decreasing...

Cell cycle checkpoints regulate progression through the cell cycle. In yeast, loss of the G2 checkpoint by mutation of the rad9 gene results in increased genetic instability as well as increased sensitivity to ionizing radiation. In contrast, comparing clonogenic survival of cells which are isogeneic except for p53 functional status, we find that loss of a G1 checkpoint in mammalian cells is no...

Acknowledgements This project was funded by a grant from the " Stichting Parkinson Fonds " , Hoofddorp, the Netherlands. We would like to thank all participants for their cooperation in the study. Abstract 1 Depression, a common non-motor symptom of Parkinson's disease (PD), is accompanied by impaired 2 decision making and an enhanced response to aversive outcomes. Current strategies to treat d...

To study changes in energy balance occurring during the initial phases of dieting, 18 adult ovariectomized female monkeys were placed on a low-fat diet, and available calories were reduced by 30% compared with baseline consumption for 1 mo. Surprisingly, there was not significant weight loss; however, daily activity level (measured by accelerometry) decreased soon after diet initiation and reac...

Alteration in normal hippocampal (HPC) function attributed to reduced parvalbumin (PV) expression has been consistently reported in schizophrenia patients and in animal models of schizophrenia. However, it is unclear whether there is an overall loss of interneurons as opposed to a reduction in activity-dependent PV content. Co-expression of PV and the constitutively expressed substance P (SP)-r...

Background Born of a child with hearing loss is a stressful and unexpected experience for the parents. Understanding the experience of the mothers of children with hearing loss is a crucial to provide an appropriate care for this group of mothers.This study aimed to understand the concerns of the mothers who have a child with congenitally hearing loss. Materials and Methods In this qualitative...

OBJECTIVE The objective was to assess whether a concurrent but independent navigation task exacerbates the effects of hearing loss on speech recognition and whether hearing loss degrades performance of the navigation task during the concurrent but independent listening task. BACKGROUND Navigation performance and speech comprehension both decrease when a driver follows hard-to-hear concurrent ...