Neurons from mouse models of Huntington's disease (HD) exhibit altered electrophysiological properties, potentially contributing to neuronal dysfunction and neurodegeneration. The renin-angiotensin system (RAS) is a potential contributor to the pathophysiology of neurodegenerative diseases. However, the role of angiotensin II (Ang II) and angiotensin (1-7) has not been characterized in HD. We i...

Introduction: Inhibition of renin angiotensin system represents an important approach in the management of cardiovascular diseases. The aim of this study was to explore the effects of pretreatment with non-hypotensive dose of angiotensin converting enzyme (ACE) inhibitor, ramiprilat and angiotensin type 1 (AT1) receptor blocker, losartan on myocardial infarct size and arrhythmias in a rat mo...

background diabetic nephropathy is the most important cause of end stage renal disease (esrd). aldosterone is involved in renal damage through induction of fibrosis, inflammation and necrosis in the kidney tissue. previous studies have demonstrated that the combination of angiotensin receptor blocker (arb) and spironolactone (an anti-aldosterone drug) are efficient for albuminuria reduction. ob...

The study was conducted to evaluate the anti-atherogenic potential of losartan and to assess the effects of hydrochlorothiazide and indapamide on losartan activity in rat. Cholesterol diet (0.5%) for 12 weeks led to significant hyperlipidemia, increased body weight and oxidative stress in erythrocyte. While, losartan, hydrochlorothiazide and indapamide treatment continued for next 12 weeks, los...

UNLABELLED The renin-angiotensin system plays a crucial role in the regulation of cardiovascular function and maintenance of water-electrolyte balance. The two major receptor types of the system, AT1 and AT2, have different, often opposite effects on these functions. AIM To elucidate the impact of long-term treatment with selective angiotensin receptor antagonists and an agonist on water-salt...

Purpose: SARS-CoV-2 infection is associated with substantial mortality and high morbidity. This study tested the effect of angiotensin II type I receptor blocker, losartan, on replication inhibition papain-like protease virus. Methods: The dose-dependent inhibitory in concentrations from 1μM to 100μM as determined by quantitative cell analysis combining fluorescence microscopy, image processing...

Angiotensin II (ANG II) plays a role in muscle wasting and remodeling; however, little evidence shows its direct effects on specific muscle functions. We presently investigated the acute in vitro effects of ANG II on resting ionic conductance and calcium homeostasis of mouse extensor digitorum longus (EDL) muscle fibers, based on previous findings that in vivo inhibition of ANG II counteracts t...

there are controversial reports about the effect of captopril on pain modulation. also while captopril may potentiate morphine analgesia, enalapril has not such an effect and interaction of morphine with angiotensin ii receptor antagonists and other angiotensin converting enzyme inhibitors has not been studied yet. therefore, this study was designed to assess the effect of captopril, lisinopril...

conclusions it may be concluded that combination of losartan with higher dose of va decreases ischemic markers and lipid peroxidation and augments endogenous antioxidant and hence, protects myocardium against i/r-induced oxidative stress injuries. results there was a more significant decrease in the levels of ldh, cpk, ck-mb, and mda as well as increase in the levels of sod, cat and gpx in grou...