Osteoarthritis (OA) is a multifactorial disease that can be caused by genetic factors, obesity, joint microtrauma, and excessive physical exercises. The key features of OA include gradual loss articular cartilage, bone tissue remodeling, development osteophytes, subchondral sclerosis. pathogenesis based on the glycosaminoglycans, collagen disorganization, inflammation mediated cytokine cascade....