Motivated by the work of Angeli and Sontag [1] and Enciso and Sontag [7] in control theory, we show that certain finite and infinite dimensional semi-dynamical systems with “negative feedback” can be decomposed into a monotone “open loop” system with “inputs” and a decreasing “output” function. The original system is reconstituted by “plugging the output into the input”. Employing a technique o...