The mammalian epididymis is a fundamental organ for sperm cell maturation; it allows mammals to acquire their fertilizing ability. We have previously shown that during obstruction in cases of vasectomy, gene expression profiles were modified in human and cynomolgus monkey epididymides. Paracrine factors thus appear to be key elements in local gene expression along the epididymis. Local renin-an...

OBJECTIVES In response to endoplasmic reticulum (ER) stress, endothelial cells initiate corrective pathways such as the unfolded protein response. Recent studies suggest that reactive oxygen species produced on the ER may participate in homeostatic signaling through Ras in response to ER stress. We sought to identify mechanisms responsible for this focal signaling pathway. APPROACH AND RESULT...

background: recurrent aphthous stomatitis (ras) is the most common inflammatory ulcerative condition of oral cavity. the aim of this study was to compare the levels of the salivary malondialdehyde (mda) and total antioxidant capacity (tac) and blood parameter in ras versus healthy controls. methods: this case-control study consisted of 28 patients with ras and 28 age and sex -matched control wi...

Background: Recurrent aphthous stomatitis (RAS) is the most common inflammatory ulcerative condition of oral cavity. The aim of this study was to compare the levels of the salivary Malondialdehyde (MDA) and total antioxidant capacity (TAC) and blood parameter in RAS versus healthy controls. Methods: This case-control study consisted of 28 patients with RAS and 28 age and sex -matched control...

among three branches of government, judiciary has the most important role in protecting of citizens’ rights; therefore upgrade and improvement of this branch is vital to promote human rights. if changes consider international standards and local concerns at the same time, be efficient, if not will be failed. good governance is an international model has localization capability which its default...

Background: Recurrent aphthous stomatitis (RAS) is a common disease, which several etiologic factors have been considered for it. The infectious agents and immunological factors are the most suspected causes. Recently a few studies with varied results have been done to clarify the role of Helicobacter Pylori (H.pylori) in etiology of RAS. Objective: To find correlations between serum IgG and Ig...

OBJECTIVE A local tissue-specific renin-angiotensin system (local RAS) has emerged as a regulator of cartilage development and homeostasis. However, no report has described the chondroprotective efficacy of RAS inhibitor. Therefore, we studied the pharmacological function of captopril on hypertrophic differentiation of chondrocytes, cartilaginous degeneration and RAS components expression in a ...