Pathogenesis of endometrial cancer has been connected with alterations of microRNA expression and in particular miR-205 up-regulation was consistently reported in this carcinoma. Presented study aimed to investigate if inhibition of miR-205 expression using LNA-modified-nucleotide would attenuate endometrial cancer cells proliferation in vitro and in vivo.In the course of the study we found tha...

BACKGROUND Locked nucleic acid (LNA) and 2'-O-methyl nucleic acid (OMeNA) are two of the most extensively studied nucleotide derivatives in the last decades. However, how they affect DNA quadruplex structures remains largely unknown. To explore their possible biological affinities for quadruplexes, we investigated how LNA- or OMeNA-substitutions affect G-quadruplex structure formation using a t...

A K-band CMOS broadband low noise amplifier (LNA) based on the magnetically coupled resonator (MCR) matching network technique is presented and implemented in 0.13-µm technology. Such LNA consists of two common-source (CS) pseudo-differential stages, which use capacitive neutralization to enhance inversion isolation Gain. The MCR-based input achieves good balance loss performance by inventing a...

Abstract This paper presents an analysis for a multi-stage Low Noise Amplifier (LNA) application on deep brain stimulation. A low noise amplifier with high gain, moderate bandwidth and reduced is designed simulated using LT Spice PTM BSIM4 CMOS models. The novel LNA circuit topology proposed which uses cascaded style to improve mid-band gain of LNA. achieves margin ranges between 60-67 (dB), 2X...

BACKGROUND & AIM The miR-221/222 cluster is upregulated in malignant plasma cells from multiple myeloma (MM) patients harboring the t(4;14) translocation. We previously reported that silencing of miR-221/222 by an antisense oligonucleotide induces anti-MM activity and upregulates canonical miR-221/222 targets. The in vivo anti-tumor activity occurred when miR-221/222 inhibitors were delivered d...

We measured the helical repeats of a non-natural nucleic acid, locked nucleic acid (LNA), by incorporating LNA strands into the outer arms of a DNA double crossover (DX) molecule; atomic force microscopy (AFM) imaging of the two-dimensional (2D) arrays self-assembled from these DX molecules allows us to derive the helical repeat of the LNA/DNA hetero-duplex to be 13.2 +/- 0.9 base pairs per turn.

* Department of Electrical Engineering, Technion, Haifa, Israel ([email protected]) We present our design methodology of a low-noise amplifier (LNA) in 0.18 μm CMOS technology. A 24-GHz LNA having peak gain of 13.8 dB and record low minimum noise figure of 2.8 dB at 25.1 GHz was demonstrated. High quality factor slow wave transmission lines replaced all inductors in the circuit. The LNA ...

Two unusual reactions involving the 5-hexenyl or the 6-heptenyl radical cyclization of a distant double-bond at C4' and the radical center at C2' of the ribofuranose ring of thymidine have been used as key steps to synthesize North-type conformationally constrained cis-fused bicyclic 5-membered and 6membered carbocyclic analogs of LNA (carbocyclic-LNA-T) and ENA (carbocyclic-ENA-T) in high yiel...

A low power 5.8 GHz fully integrated CMOS low noise amplifier (LNA) with on chip spiral inductors for wireless applications is designed based on TSMC 0.18 μm technology in this paper. The cascode structure and power-constrained simultaneous noise and input matching technique are adopted to achieve low noise, low power and high gain characteristics. The proposed LNA exhibit a state of the art pe...

Genotyping of single nucleotide polymorphisms (SNPs) in large populations presents a great challenge, especially if the SNPs are embedded in GC-rich regions, such as the codon 112 SNP in the human apolipoprotein E (apoE). In the present study, we have used immobilized locked nucleic acid (LNA) capture probes combined with LNA-enhancer oligonucleotides to obtain efficient and specific interrogat...