The ability of recombinant human tumor necrosis factor (rH-TNF) alone or in combination with lymphokines (LK) to induce the in vitro activation of murine macrophages was evaluated. The treatment of C57BL/6 mouse resident peritoneal exÃodatecells (PEC) with rH-TNF and LK was found to induce the activation of macrophages to a tumoricidal state against P815 mastocytoma cells. Neither rH-TNF nor LK...

The present study was designed to explore the mechanisms involved in the anti-ischemic action of lumbrokinase (LK) in brain. The enzyme immunoassay, spectrofluorimeter and flow cytometry were used to detect the level of adenosine 3',5'-cyclic monophosphate (cAMP) and guanosine 3',5'-cyclic monophosphate (cGMP), the Ca(2+) mobilization, and human platelet surface antigen expression in order to e...

We show that if M is a DFA with n states over an arbitrary alphabet and L = L(M), then the worst-case state complexity of L2 is n2 − 2n−1. If, however, M is a DFA over a unary alphabet, then the worst-case state complexity of L is kn− k + 1 for all k ≥ 2.

Red cells from newborn lambs were separated into different age populations by centrifugation, and cells with fetal hemoglobin (Hb) were distinguished from those with adult Hb by an acid elution technique. Changes were followed during development in rates of K+ transport (active and passive), numbers of Na+/K+ pump sites per cell, cell volumes, and numbers of Lp and L1 antigen sites per cell. Th...

The symmetric numerical semigroups S (Fa, Fb, Fc) and S (Lk, Lm, Ln) generated by three Fibonacci (Fa, Fb, Fc) and Lucas (Lk, Lm, Ln) numbers are considered. Based on divisibility properties of the Fibonacci and Lucas numbers we establish necessary and sufficient conditions for both semigroups to be symmetric and calculate their Hilbert generating series, Frobenius numbers and genera.

Oral cancer generally progresses from precancerous lesions such as leukoplakia (LK), lichen planus (LP) and oral submucous fibrosis (OSMF). Since few of these precancers progress to cancers; it is worth to identify biological molecules that may play important roles in progression. Here, expression deregulation of 7 miRNAs (mir204, mir31, mir31*, mir133a, mir7, mir206 and mir1293) and their poss...

Clustering is a relevant problem in machine learning where the main goal is to locate meaningful partitions of unlabeled data. In the case of labeled data, a related problem is supervised clustering, where the objective is to locate classuniform clusters. Most current approaches to supervised clustering optimize a score related to cluster purity with respect to class labels. In particular, we p...

The Fisher-inspired, arbitrary intersexual selection models of Lande (1981) and Kirkpatrick (1982), including both stable and unstable equilibrium conditions, provide the appropriate null model for the evolution of traits and preferences by intersexual selection. Like the Hardy–Weinberg equilibrium, the Lande–Kirkpatrick (LK) mechanism arises as an intrinsic consequence of genetic variation in ...