نتایج جستجو برای: liver protection
تعداد نتایج: 500048 فیلتر نتایج به سال:
Background & AimsAlthough type 2 innate lymphoid cells (ILC2s) were originally found to be liver-resident lymphocytes, the role and importance of ILC2 in liver injury remains poorly understood. In current study, we sought determine whether is an important regulator hepatic ischemia/reperfusion (IRI).MethodsILC2 deficient mice (ICOS-T or NSG) genetically modified ILC2s used investigate murine IR...
Whole malaria sporozoite vaccine regimens are promising new strategies, and some candidates have demonstrated high rates of durable clinical protection associated with memory T cell responses. Little is known about the anatomical distribution of memory T cells following whole sporozoite vaccines, and immunization of nonhuman primates can be used as a relevant model for humans. We conducted a ch...
damage the liver. Drug-induced liver injury is the most frequent cause of acute liver failure. Dimethylnitrosamine (DMN) is a potent hepatotoxin, carcinogen and mutagen. A high dose of DMN is administrated by one injection to the experimental animal, which causes submassive necrosis that resembles human fulminant hepatitis. Therefore this compound has been widely used as a model agent to study ...
Evidence is presented that there are differences between pig liver and kidney parenchymal cells in the expression of major histocompatibility complex antigens. Analogues of I-region antigens of the mouse are detectable on kidney cells and some peripheral blood leukocytes (PBL) but not on liver, platelets, and other PBL. Such differences between liver and kidney may explain (a) the fate of these...
The liver is a major organ that controls hepatic and systemic homeostasis. Dysregulation of liver metabolism may cause liver injury. Previous studies have demonstrated that carboxylesterase 1 (CES1) regulates hepatic triglyceride metabolism and protects against liver steatosis. In the present study, we investigated whether CES1 played a role in the development of alcoholic liver disease (ALD) a...
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