BACKGROUND Live attenuated influenza vaccines (LAIV) against a variety of strains of pandemic potential are being developed and tested. We describe the results of an open-label phase I trial of a live attenuated H2N2 virus vaccine. OBJECTIVES To evaluate the safety, infectivity, and immunogenicity of a live attenuated H2N2 influenza virus vaccine. PARTICIPANTS/METHODS The A/Ann Arbor/6/60 (...

The Sterne live spore vaccine (34F2) is the most widely used veterinary vaccine against anthrax in animals. Antibody responses to several antigens of Bacillus anthracis have been described with a large focus on those against protective antigen (PA). The focus of this study was to evaluate the protective humoral immune response induced by the live spore anthrax vaccine in goats. Boer goats vacci...

in the present study, 360 male day-old broiler chicks were used to determine the effect of mixed livevaccines of newcastle disease (nd) and infectious bronchitis (ib) on serum and local antibody responses toib. chicks were randomly divided into 12 treatment groups of 3 replicates and reared for 40 days on floorpens. groups 1 to 5 received mixed nd and ib vaccine. groups 7 to 11 received ib vacc...

BACKGROUND Live attenuated influenza vaccines have been shown to significantly reduce influenza in diverse populations of children, but no efficacy studies have been done in resource-poor tropical settings. In Senegal, we assessed the efficacy and safety of a live attenuated influenza vaccine based on Russian-derived master donor viruses and licensed as a single dose. METHODS In this double-b...

MBRIIHUNA A similar reduction in incidence was shown among those children who were known to be in contact with measles in their own homes and presumably exposed to heavy infection. The attack rates in a representative sample of children exposed at home were 9% in the killed/live-vaccine group, 6%, in the live-vaccine group, and 83 % in the unvaccinated group. Those children who defaulted from v...

Objective(s): Vaccination is one of the most effective means to protect humans and animals against brucellosis. Live attenuated Brucella vaccines are considered effective in animals but they may be potentially infectious to humans, so it is vital to improve the immunoprotective effects and safety of vaccines against Brucella. This study was designed to evaluate the immunogenicity of DNA vaccine...

In the editorial note on Controlled Drugs which I contributed to the issue of September 9 (Canad. M. A. J., 85: 661, 1961), I find that I have overstated the case for written prescriptions for the amphetamines and the barbiturates. Pharmacists may dispense Controlled Drugs on the strength of a prescription given verbally by a physician as well as by a prescription in writing. The pharmacist mus...

Poliomyelitis associated with live strain vaccine is defined as the paralytic form of the acute anterior poliomyelitis related to the vaccine strain. Since these strains behave similarly to the wild-type virus, we can differentiate, epidemiologically, two types of vaccine-associated poliomyelitis: cases in which the patient was vaccinated and cases in which the patient had had contact with vacc...