the purpose of this study was to compare the effectiveness of three common mood stabilizing drugs, lithium, carbamazepine and valproate in the treatment of acute mania of the 114 patients who participated in this study, 60 were treated with lithium, 30 with carbamazepine and 24 with valproate. this study was a prospective and double blind study. the patients were assessed by gaf scale and a man...

BACKGROUND In spite of recent enrichment of neurochemical and behavioural data establishing a neuroprotective role for lithium, its primary effects on cognitive functioning remain ambiguous. This study examines chronic lithium effects on spatial working memory and long-term retention. METHODS In three discrete experiments, rats subjected to 30 daily intraperitoneal injections (2mmol/kg) of li...

BACKGROUND Women taking lithium must decide whether to continue the medication if they conceive or plan to conceive. Little is known about the extent of prescribing of lithium during pregnancy. AIMS To determine: 1) the prevalence of lithium prescribing during pregnancy and 2) to assess whether pregnancy is associated with discontinuation of lithium. METHOD First, we identified women receiv...

Objective(s): Neurodegeneration is an outcome of Methamphetamine (METH) abuse. Studies have emphasized on the neuroprotective properties of lithium. The current study is designed towards evaluating the role of Akt-1/GSK3 and CREB-BDNF signaling pathways in mediating lithium neuroprotection against METH-induced neurodegeneration in rats. Materials and ...

Lithium metal is an ideal battery anode. However, dendrite growth and limited Coulombic efficiency during cycling have prevented its practical application in rechargeable batteries. Herein, we report that the use of highly concentrated electrolytes composed of ether solvents and the lithium bis(fluorosulfonyl)imide salt enables the high-rate cycling of a lithium metal anode at high Coulombic ef...

We would like to comment on the interesting case report of lithium intoxication reported by Jing Peng. An 18-year old female with mania developed confusion, trembling extremities, slurred speech, increased muscle tension, and hyperactive tendon reflexes 20 days after initiating treatment with routine dosages of lithium bicarbonate. When admitted to the hospital due to her acute neurological con...

BACKGROUND Lithium has been the treatment of choice for bipolar disorder (BD) for many years. Although erectile dysfunction is a known adverse effect of this drug, the mechanism of action by which lithium affects erectile function is still unknown. OBJECTIVE The aim was to investigate the possible involvement of nitric oxide (NO) in modulatory effect of lithium on penile erection (PE). We fur...

The formation of lithium dendrites induces the notorious safety issue and poor cycling life of energy storage devices, such as lithium-sulfur and lithium-air batteries. We propose a surface energy model to describe the complex interface between the lithium anode and electrolyte. A universal strategy of hindering formation of lithium dendrites via tuning surface energy of the relevant thin film ...