Lithium is one of the most commonly used drugs in the prophylaxis and treatment of bipolar disorder. The mechanisms of mood stabilization by lithium incorporate its effect on serotonergic neurotransmission. This paper investigates a relationship between response to lithium prophylaxis and polymorphisms in two genes: T102C of 5-HT2A receptor and G68C (Cys23Ser) of 5-HT2C serotonin receptor gene....

A 33-year-old man with bipolar affective disorder presented with acute onset of rigidity, tremors, and confusion. He had been taking oral lithium (1,200 mg daily) for the past 2 months. Baseline blood, EEG, and CSF analyses were normal. Serum lithium level was 0.67 mEq/L (0.3–1.3). GadoliniumMRI brain showed multiple bilateral symmetric T2-weighted hyperintensities (figure, A–C). On suspicion o...

Lithium was first discovered as a chemical element in 1817. By the mid-1800s, there was great interest in “urate imbalances”, which were thought to explain a variety of diseases, including mania and depression. Around this time, it was discovered that a solution of lithium carbonate could dissolve stones made of urate. The first recorded use of lithium for the treatment of mania, based in part ...

Our initial primary goal was to examine energy sources for improving small-glider performance. The energy source is a critical design choice for any autonomous vehicle. Today’s gliders usually use selfcontained lithium primary batteries. Based on reaction energy and reactant mass, oxidation of lithium is a particularly high energy density option. Each gram of lithium supplies 3.8 A-hr of curren...

EFFECTS OF LITHIUM TREATMENT ON GRANULOCYTES AND GRANULOCYTE COLONY-STIMULATING FACTOR IN PATIENTS WITH BIPOLAR AFFECTIVE DISORDER Objective: Although there are conflicting results, lithium carbonate has been demonstrated to induce the production of haematopoietic cells, particularly white blood cell series. In this study, we examined the effects of lithium on white blood cells in association w...

OBJECTIVE Growing evidence suggests that abrupt lithium discontinuation increases the risk of recurrence for patients with bipolar disorder. To assess the effect of abrupt change in lithium dose, the authors reanalyzed data from a previously reported, randomized, double-blind trial of standard- versus low-dose lithium for maintenance therapy in bipolar disorder. METHOD In the original study, ...

The lithium ion-ion interactions in protic ionic liquids can be very different compared to those in aprotic ionic liquids. In this study we show that, for equal lithium ion concentration, the lithium coordination number in protic ionic liquids is lower than that in aprotic ones. This lower coordination makes lithium ions more "free" to move in protic ionic liquids and it might have an important...

Lithium, manic-depressive illness, and psychological test performance For over 10 years patients responding to treatment at a lithium clinic' have been free from psychiatric symptoms. Little is known about the psychological performance of such patients, but a report,2 using the Minnesota Multiphasic Personality Inventory (MMPI), confirmed that lithium produces a response in depression. Clinical...

57% of a group of 35 patients treated with Lithium Carbonate at dosages predicted by the nomogram suggested by Cooper et al (1973) failed to reach therapeutic levels of serum lithium. This finding casts serious doubts on the usefulness of the claim by Cooper et al (1973 & 1976) that 24 hour serum lithium level after a test dose of 600 mg. lithium can predict the daily lithium dose.

Two model compounds, lithium imidazolium (LiIm) and lithium 2-undecylimidazolium (und-LiIm), were synthesized. These materials are chosen as models of potential lithium ion conductors for use as electrolytes in lithium batteries. Solid-state NMR was used to provide information on the microscopic interactions including ionic mobility and ring reorientations which govern the efficiency of conduct...