Pantethine is the stable disulfate form of pantetheine, the metabolic substrate which constitutes the active part of coenzyme A (CoA) molecules and acyl carrier proteins. Because pantethine is located nearer to CoA than is pantothenic acid in the biosynthetic pathway of CoA, it has been suggested it will have clinical benefits in conditions where pantothenic acid is not effective, and clinical ...

The “cobalt” variant of rainbow trout Oncorhynchus mykis lacks most of the pars intermedia of the pituitary in which melanocyte-stimulating hormone (MSH) cells are distributed. An excessive accumulation of fat in the abdominal cavity is also observed in variant. In this study, the role of MSH on lipid metabolism of the trout and the possible relation to fat accumulation in the cobalt variant we...

Studies have been made of the effect of excess dietary choline upon the arteriosclerosis produced in dogs by a regimen of cholesterol and thiouracil feeding. The choline-fed animals did not differ significantly from the control animals with respect to serum lipid levels, degree of lipid infiltration of their livers or severity of arteriosclerotic involvement. C HOLINE is currently being promote...

Replacement of the terminal methyl group of methionine by an ethyl group gives the substance ethionine. Ethionine has been shown to be an antimetabolite of methionine in a number of biological systems in that inhibition by ethionine is reversed by methionine (16, 35). The precise mode of action is not certain; it probably varies from one organism to another. Present evidence from work on animal...

the six elements commonly known as metalloids are boron, silicon, germanium, arsenic, antimony, and tellurium. metalloid containing compounds have been used as antiprotozoal drugs. boron-based drugs, the benzoxaboroles have been exploited as potential treatments for neglected tropical diseases. arsenic has been used as a medicinal agent and arsphenamine was the main drug used to treat syphilis....

Phases having compositional fields narrower than about 1 at.% and appearing as lines in binary phase diagrams often are assumed to have properties independent of composition. That such an assumption can be seriously in error is illustrated by recent measurements on pairs of samples prepared to have compositions at opposing phase boundaries. Two microscopic properties, lattice locations of highl...