OBJECTIVE Glucolipotoxicity is a major pathophysiological mechanism in the development of insulin resistance and type 2 diabetes mellitus (T2D). We aimed to detect subtle changes in the circulating lipid profile by shotgun lipidomics analyses and to associate them with four different insulin sensitivity indices. METHODS The cross-sectional study comprised 90 men with a broad range of insulin ...

A simple method for the rigorous derivation of lithogenic index or percent cholesterol saturation, embodying both relative and total lipid concentrations, is described. We recently demonstrated that under physiological conditions only two key physical-chemical variables, the bile salt-lecithin ratio and the total lipid (bile salts + lecithin + cholesterol) concentration determine the equilibriu...

Lipids are essential components of biological membranes, lipoproteins and metabolic regulators that control cellular function and homeostasis. The lipid profile indicates whether there is a problem in metabolizing lipids (metabolic syndrome), or consumption of a high-fat or high-cholesterol diet. Lipid profile and body fat have been shown to be the important predictors for metabolic disturbance...

AIMS Compared with intravascular ultrasound (IVUS), optical coherence tomography (OCT) has relative merits and demerits for detecting plaque characteristics. It remains unknown whether the IVUS and OCT evaluations of plaque progression/regression are consistent. We sought to analyse the correlations between IVUS and OCT evaluations of plaques at single time points, and compare temporal changes ...

Diabetic nephropathy is the single most common disorder leading to renal diseases. Reactive oxygen species (ROS) play a major role in the development of diabetic nephropathy. Nephrotic syndrome is often manifesting in progression of diabetic nephropathy. Therefore, this study was carried out to investigate oxidant and antioxidant status in diabetic nephropathy patients. The blood samples were a...

Although intensive lipid lowering by statins can enhance plaque stability, few data exist regarding how early statins change plaque composition and morphology in clinical setting. Therefore, to examine early changes in plaque composition and morphology by intensive lipid lowering with statins, we evaluate coronary plaques from acute coronary syndrome (ACS) before and 3 weeks after lipid lowerin...

BACKGROUND Skeletal muscle lipid is associated with obesity and type 2 diabetes and may be altered by diet, physical activity, and weight loss. OBJECTIVE We explored the utility of magnetic resonance imaging (MRI) for quantifying the lipid concentration of muscle tissue in vivo. DESIGN Fat-selective MR images of the lower leg were taken in 8 normal-weight [body mass index (in kg/m(2)) < or ...

introduction: ramadan is a holy month for muslims during which avoid from eating, drinking and sexual intercourse for about 13-17 hours. the aim of this study was surveying the effects of islamic fasting in ramadan on lipid profile and blood pressure.materials and methods: we designed this study in two phases, a week before and a week after ramadan month. eighty nine healthy subjects with 20-50...

PURPOSE The differential diagnosis of dry eye syndrome is still a challenging task. The purpose of this study was to understand the relationship between a novel, objective clinical parameter, the "corrected lipid layer stabilization time," and commonly performed clinical tests for dry eye patients. METHODS Data were obtained from a prospective clinical study with 59 patients of different subj...