Circadian factors might play a crucial role in the etiology of depression. It has been demonstrated that the disruption of circadian rhythms by lighting conditions and lifestyle predisposes individuals to a wide range of mood disorders, including impulsivity, mania and depression. Also, associated with depression, there is the impairment of circadian rhythmicity of behavioral, endocrine, and me...

An evolutionary stage model of cyberspace is proposed based on the four key fundamental driving forces: Moore’s Law, Gilder’s Law, Metcalfe’s Law, and the Law of Disruption. It is suggested that the managerial tasks and information and communication technologies associated with the utilization of cyberspace will change in character over a period of time, and will evolve in patterns roughly rela...

An increasing body of evidence implicates proinflammatory cytokines in psychiatric disorders, namely, in depression. Of notice, recent studies showed that anti-inflammatory cytokines, such as IL-10, also modulate depressive-like behavior. In this article, we propose that the anti-inflammatory cytokine IL-10 is a putative link between two of the most widely reported phenomenon observed in depres...

Electrical stimulation of the human cortex typically elicits positive sensorimotor effects. However, many neurosurgical studies have also reported negative motor areas (NMAs) in which stimulation produces inhibition of ongoing movement. The neurocognitive implications of these studies have not been systematically explored. Here we review the neurosurgical literature on NMAs and link this to cog...

Assessing network systems for failures is critical to mitigate the risk and develop proactive responses. In this paper, we investigate devastating consequences of link failures in networks. We propose an exact algorithm and a spectral lowerbound on the minimum number of removed links to incur a significant level of disruption. Our exact solution can identify optimal solutions in both uniform an...

This document describes a mechanism for a restarting router to signal to its neighbors that it is restarting, allowing them to reestablish their adjacencies without cycling through the down state, while still correctly initiating database synchronization. This document additionally describes a mechanism for a restarting router to determine when it has achieved Link State Protocol Data Unit (LSP...

Tumor suppressor proteins protect cells and tissues from malignant transformation. Among their diverse actions, many of these proteins interact with the microtubule cytoskeleton. This review focuses on the interactions of several tumor suppressors with microtubules and speculates on how disruption of microtubule-dependent processes may contribute to cancer development and spread. We conclude th...

Sensor networks represent a powerful new data paradigm facilitating the development of new intelligent applications. In support of mission critical applications such as surveillance, sensors can be made to operate effectively in their deployed environments by adopting a “situation awareness” perspective. In this paper we present and adapt our VIGILANT “situation aware” system architecture to ca...

The c-Jun NH(2)-terminal kinase (JNK) is activated when cells are exposed to environmental stress, including UV radiation. Gene disruption studies demonstrate that JNK is essential for UV-stimulated apoptosis mediated by the mitochondrial pathway by a Bax/Bak-dependent mechanism. Here, we demonstrate that JNK phosphorylates two members of the BH3-only subgroup of Bcl2-related proteins (Bim and ...

Wormhole attack is a Routing-Disruption Attack in ad hoc networks, those malicious nodes in these networks can bear wormhole attacks to make up a false scenario on neighbor discovery relations among mobile nodes. The attackers endanger the safety of ad hoc routing protocols with making a direct link, referred to as a wormhole tunnel, between malicious nodes. After building a wormhole tunnel, on...