Background: Because of high morbidity of the brucellosis in humans and the potential use of the microorganism as an agent of biologic warfare, protection of effective vaccines and specific diagnostic reagents become necessary to eradicate brucellosis. Objective: In this study we aimed to investigate the cytokine responses and changes in peripheral blood lymphocyte subgroups of acute brucellosis...

To explore the role of Toll-like receptors (TLRs) and interferon (IFN) in innate immunity against porcine epidemic diarrhea virus (PEDV), we detected expression TLR genes PEDV-infected IPEC-J2 cells by real-time PCR. We also level α (IFN-α) γ (IFN-γ) enzyme-linked immunosorbent assay (ELISA). Results showed that exhibited a clear pathological change after PEDV infection at 24 h. In addition, TL...

background: periodontitis is an inflammatory disease of tooth-supporting tissues. the present study was conducted to evaluate interleukin-10 (il-10) and interferon gamma (ifn-γ) levels in gingival crevicular fluid (gcf) of patients with chronic periodontitis. materials and methods: this case-control study was carried out on 60 men including 30 smokers and 30 age-matched non-smokers. the assessm...

multiple sclerosis (ms) is an inflammatory, multifocal, immune-mediated disease of the central nervous system that women are at a higher risk to acquire than men. myxovirus resistance protein a (mxa) is used as a predictive marker of bioactivity of interferon-beta (ifn-β) therapy in ms patients. this study was undertaken in west of iran to investigate gender differences in the expression level ...

background: the relationship of inflammatory cytokines with anxiety and depression has been reported, but their role in diabetic patients has not been fully elucidated. objective: we examined whether an association between prevalence of anxiety and depression in omani type-2 diabetic patients (n=30) and the levels of inflammatory markers such as il-1β, tnf-α, ifn-γ and c-reactive protein (crp) ...

chemokines are classified in four distinct groups as cxc, cc, cx3c and c, depending on the presence or absence of a motif called elr (arg-leu-glu) before the first cysteine residue in their structure. cxc chemokines are also subdivided into elr + and elr - . increasing evidence has indicated the existence of a chemokine network in the liver which is involved in both physiological responses and,...

about 25-50% of graves' disease (gd) patients develop thyroid eye diseases, which is associated with inflammatory process and abnormalities in the levels of several cytokines in orbital tissues in gd.  the aim of this study was to determine the th1 and th2 serum cytokines in patients with gd with or without ophthalmopathy. serum  levels of  cytokines  and  autoantibodies  including interferon-g...