objective(s) there are some reports in recent years indicating that renal ischemia - reperfusion (ir) induces deleterious changes in remote organs such as liver. the aim of this study was to investigate whether leukocytes have a role on the induction of oxidative stress in liver after renal ir. materials and methods inbred mice in ir donor group were subjected to renal ir injury. in sham donor ...

background: nanoparticles have become one of the leading technologies over the past two years. the extensive use of nanoparticles has raised great concern about their occupational fate and biological effects. with an increase in the production and use of nanomaterial, it is more likely to get exposed to them occupationally and environmentally. objective: to assess the toxicity of silver nanopar...

Several clinical and biologic factors have been found to be significant predictors of outcome in childhood acute lymphoblastic leukemia (ALL), including age, presenting leukocyte count, immunophenotype, recurrent chromosomal abnormalities, and response to initial therapy as assessed by light microscopy as well as more sensitive measures of submicroscopic disease. Over the last several decades, ...

A 63-year-old Japanese woman with advanced lung adenocarcinoma developed isolated adrenocorticotropin deficiency caused by immune checkpoint inhibitor (ICI)-related hypophysitis following 8 months of nivolumab therapy. Prompt corticosteroid replacement therapy effectively relieved her secondary adrenal insufficiency symptoms and allowed her to pursue nivolumab therapy, which had been effective ...

I N 1985, a review article appeared in this journal that examined the interactions of leukocytes with vascular endothelium during an immune or inflammatory response.’ The basic physiology of leukocyte emigration as well as disease states in which alterations of leukocyte-endothelial interactions may contribute to pathology were discussed. Since then there has been an explosion of interest in th...

Leukocyte adhesion deficiency type 1 (LAD1) is a rare congenital immunodeficiency disease. The cause of disease determined to be the mutations in ITGB2 gene that codes for CD18, beta chain beta-2 integrins, leads decreased expression or functioning CD18. This severe impairment leukocyte vascular wall and migration sites infection inflammation. LAD1 has also been associated with inhibition inter...