Tissue Plasminogen Activator 7351C/T Polymorphism and Lacunar Stroke To the Editor: Jannes et al1 reported that a polymorphism in the tissue plasminogen activator (tPA) gene ( 7351C/T) was associated with ischemic stroke in an Australian population. Stratification for stroke subtype demonstrated an association with lacunar infarction (OR: 2.7; 95% CI, 1.1 to 6.7), but not with other stroke subt...

Leukoaraiosis is associated with increased risk of cognitive impairment, but its pathophysiological pathway is unclear. The aim of the present study was to determine whether brain structural damage or cerebral blood supply better correlated with the global cognitive outcome in subjects with leukoaraiosis. Seventy-five subjects with leukoaraiosis were included in present study, with age ranged f...

In patients with dementia, leukoaraiosis (LA) was hypothesized to result in differential patterns of impairment on a verbal serial list-learning test. Using a visual rating scale, 144 dementia patients with ischemic scores <4 were re-categorized as having mild (n = 73), moderate (n = 44), or severe LA (n = 27). Mild LA was predicted to be associated with an amnestic list-learning profile, while...

BACKGROUND AND PURPOSE We investigated whether lacunar infarct (LI) patients with >1 lacune have different vascular risk factors, a different prognosis, and poorer functional outcome than those with a single lacune. METHODS The study included 175 first-ever LI patients. The group was divided according to the presence of multiple (n=136) or single (n=39) LI. The association of single or multip...

BACKGROUND The detection of early neuropsychological abnormalities as precursors of cognitive decline of vascular origin in patients with lacunar stroke is a subject of increasing interest. The objective of this study was to assess whether there were differences in the performance of a battery of neuropsychological tests in first-ever lacunar stroke patients with and without associated silent m...

background: leukoaraiosis (la) or white matter thinning and rarefaction are common in stroke patients. this pilot double-center study was designed to evaluate la risk factors in stroke patients.   methods: this cross sectional study was conducted on 100 consecutive stroke patients in walter mackenzie hospital, canada and 100 consecutive stroke patients in valie-asr hospital , iran in 2004. diag...