Diffuse cutaneous leishmaniasis is a rare form of characterized by an inadequate immune response the host cells to parasitic invasion (weak T-helper (Th)1 or Th2 with production interleukin (IL)-4 and IL-10). The characteristic features disease include diffuse nodular eruption, masquerading as leprosy frequent association immunosuppression (HIV co-infection, for example). Russian Federation non...

Background an objective: Leishmaniasis is a common disease endemic in some parts of Iran. Chemical or physical treatments or a combination of both are used for treatment of the disease. Nitric oxide (NO) is important for healing of leishmaniasis in human and animal. This study was designed to evaluate the beneficial effects of a NO releasing cream on cutaneous leishmaniasis in an animal m...

BACKGROUND Visceral Leishmaniasis coinfection with HIV/AIDS has emerged as a series of disease pattern. It most often results in unfavorable responses to treatment, frequent relapses, and deaths. Scarce data is available regarding the prevalence of HIV and associated factors among Visceral Leishmaniasis coinfected patients. This study sought to determine the prevalence of HIV and associated fac...

As part of a World Health Organization-led effort to update the empirical evidence base for the leishmaniases, national experts provided leishmaniasis case data for the last 5 years and information regarding treatment and control in their respective countries and a comprehensive literature review was conducted covering publications on leishmaniasis in 98 countries and three territories (see 'Le...

Cutaneous leishmaniasis is a major public health problem as disease endemic in Iraqi population. Manydiagnostic tools are used to establish the diagnosis like smear, histopathology and culture. To find morerapid, sensitive specific diagnostic method for of cutaneous leishmaniasis, detectthe genotypes leishmania tropica strains Iraq. Sixty six patients (43 males and23 females) with clinical were...

Since July 2009, there has been a community outbreak of leishmaniasis in the south-west area of the Madrid autonomous community, Spain, affecting residents from four towns that are geographically close together and share extensive park areas. As of December 2012, 446 cases were reported (6 in 2009, 97 in 2010, 196 in 2011 and 147 in 2012), a mean incidence rate of 22.2 per 100,000 inhabitants d...

Visceral leishmaniasis (VL) is a severe and often fatal form of caused by Leishmania donovani in the Indian sub-continent. Post Kala-azar Dermal Leishmaniasis (PKDL) late cutaneous manifestation VL, typically occurring after apparent cure but sometimes even without prior history VL India. PKDL serves as significant yet neglected reservoir infection plays crucial role transmission disease, posin...

Human visceral leishmaniasis, one of the most important zoonoses, is caused by the protozoa Leishmania chagasi (syn. L. infantum) and is present as a fatal disease common in South America and Europe where dogs and wild canids are the main reservoirs. A vaccine against visceral leishmaniasis would be an important tool in the control of this disease in dogs. Although the current strategies for va...

BACKGROUND Ficolin-2 coded by FCN2 gene is a soluble serum protein that plays an important role in innate immunity. In this study, we analyzed five functional polymorphisms of the FCN2 gene for their possible association with cutaneous leishmaniasis. METHODS Initially we screened 40 Syrian Arabs for the entire FCN2 gene. We investigated the contribution of FCN2 functional variants in 226 pati...

To the Editor: In Afghanistan, most cutaneous leishmaniasis cases are caused by Leishmania tropica, which is transmitted anthroponotical-ly by the sandfly Phlebotomus sergen-ti (1). Cutaneous leishmaniasis can have devastating effects on local communities because of its clinical symptoms , i.e., large, multiple, or both, disfiguring lesions, that can lead to social ostracism of affected persons...