Oxygen tension in healing tissues is heterogeneous. Increased oxygen mostly stimulates repair mechanisms and enhances tissue healing. Hyperbaric oxygen therapy increases blood and tissue oxygen content and may help maintain cellular integrity and function. Hydroxyurea (HU) is a cytotoxic agent, which leads to inactivation of ribonucleotide reductase, inhibition of cellular DNA synthesis, and ce...

Martorell ulcer is a form of lower limb ulceration, preceded by a small area of excruciating pain. It often appears as a solitary lesion on the outer aspect of the lower limb, and is primarily associated with poorly controlled hypertension and diabetes. Treatment of the ulcer involves awareness and early correct diagnosis, adequate control of blood pressure, management of infection, and wound c...

Leukocytoclastic vasculitis is a rare cutaneous manifestation in multiple myeloma and only twenty cases have been described to date. We report an unusual case with kappa IgA 63 years old woman presented leukocytoclastic type of digital necrosis leg ulcer. The seems be paraneoplastic as skin lesions regressed following treatment.

Much research has been undertaken into the cost-effectiveness of leg ulcer treatments, dressing selections and patient compliance. However, comparatively little research has investigated the effect of leg ulcers on patients' quality of life. This article reviews the literature examining the quality of life of this patient group and the factors that have the greatest negative impact on them.

DOI: 10.5581/1516-8484.20120018 Chronic leg ulceration affects about 1% of the population at some point in their lives. Additionally, leg ulcers are one of the sequels of sickle cell disease with physiological and psychosocial consequences.(1) Treatment aims at improving the quality of life of patients and effectively healing the lesion. Adherence to treatment is not always effective, especiall...

OBJECTIVES To establish the relative cost effectiveness of community leg ulcer clinics that use four layer compression bandaging versus usual care provided by district nurses. DESIGN Randomised controlled trial with 1 year of follow up. SETTING Eight community based research clinics in four trusts in Trent. SUBJECTS 233 patients with venous leg ulcers allocated at random to intervention (...

AIM To conduct a cost-effectiveness analysis based on data from a randomised controlled trial comparing traditional community home nursing with a community Leg Club model for chronic venous leg ulcer management in the south-east metropolitan area of Queensland, Australia. METHOD Participants were randomised to the Leg Club (n=28) or home visits (n=28). Data were obtained on resources/related ...

OBJECTIVE To determine family physicians' perceptions of and attitudes toward leg ulcer care and awareness of effective treatments for venous leg ulcers. DESIGN Self-administered, cross-sectional faxed and mailed survey. SETTING Ottawa-Carleton, Ont. PARTICIPANTS All physicians in the region who were members of the College of Family Physicians of Canada. RESULTS Response rate was 62%. D...

BACKGROUND Judgements and decisions about venous leg ulcer management are characterised by uncertainty. Good judgements and reduced variations in practice require nurses to identify relevant "signals" in clinical encounters. Nurses, even experienced ones, vary in their ability to separate these signals from surrounding noise. OBJECTIVES Examine specialist and generalist nurses' discrimination...