Perfusion abnormalities in the pressure-overloaded hypertrophied left ventricle could result from an increase in minimum coronary resistance or an increase in effective back pressure due to increased extravascular compressive forces. Since the pressure-flow relation of the maximally vasodilated coronary bed allows dissociation of minimum resistance (inverse slope [1/acPFI) and back pressure (pr...

MULLINS,~HARLES B., WINFRED L. SUGG,BRIAN M. KENNELLY, DAN C. JONES, AND JERE H. MITCHELL. Effect of arterial counterpulsatil>n on left ventricular volume and pressure. Am. J. physiol. 220(3) : 694-698. 197 1 .-The influence of arterial counterpulsation by means of the SIMAS circulatory assist device on left ventricular volume and pressure was studied. Fifteen studies in nine dogs were complete...

Perfusion abnormalities in the pressure-overloaded hypertrophied left ventricle could result from an increase in minimum coronary resistance or an increase in effective back pressure due to increased extravascular compressive forces. Since the pressure-flow relation of the maximally vasodilated coronary bed allows dissociation of minimum resistance (inverse slope [1/acPFI) and back pressure (pr...

INTRODUCTION Left ventricular hypertrophy and diastolic dysfunction in children and adolescents with essential hypertension tend to be underdiagnosed. The aims of this study were to investigate left ventricular hypertrophy and diastolic dysfunction in the subjects with essential hypertension defined by ambulatory blood pressure monitoring. METHODS A total of 38 Korean subjects aged 9-19 years...

With the technique of right atrial pacing, left ventricular function was assessed in 21 normal subjects and in 13 patients with elevated left ventricular filling pressures. Since cardiac output does not change significantly with atrial pacing, the stroke volume decreases as an inverse function of the pacing rate. Stroke volume can thus be varied over a wide range, and by simultaneous measuremen...

1. Continuous intra-arterial ambulatory monitoring of blood pressure was recorded in 46 patients with mild to moderate hypertension under standardized conditions. M-mode echocardiography was performed after recording and left ventricular mass index calculated by standard formulae. 2. Systolic blood pressure from continuous recording was significantly correlated with left ventricular mass index ...

The mechanism of elevation of left ventricular end-diastolic pressure during acute global ischemia was evaluated by examiniation of the relative contributions of a decrease in contractility and an alteration of the pressure-volume relationship. The external circumference (mercury-in-silastic gauge) pressure relationship, as an index of the pressure-volume relationship, was studied in beta adren...

BACKGROUND Obstructive sleep apnea subjects the failing heart to adverse hemodynamic and adrenergic loads and may thereby contribute to the progression of heart failure. We hypothesized that treatment of obstructive sleep apnea by continuous positive airway pressure in patients with heart failure would improve left ventricular systolic function. METHODS Twenty-four patients with a depressed l...

Left ventricular hypertrophy in left ventricular pressure overload occurs in response to excessive work load imposed on the left ventricle by increased impedance to ejection. Right ventricular hypertrophy may occur in patients with these findings, but has been considered to be secondary to pulmonary hypertension. To determine the frequency of right ventricular hypertrophy and its relation to in...

In order to assess left ventricular function in patients with rheumatic mitral stenosis, left ventricular function curves (plotting stroke work index vs left ventricular end-diastolic pressure) were constructed using angiotensin to augment, and nitroprusside to reduce, afterload. Hemodynamic responses to these alterations in afterload were measured. Resting ejection fractions and qualitative as...