introduction: in the present study, the effect of an inducible no synthase (inos) inhibitor, aminoguanidine (ag) on lipopolysaccharide (lps)-induced memory impairment and oxidative stress and inflammation parameters was evaluated. materials and methods: the rats were divided into 5 groups and treated: 1) control (saline), 2) lps (1 mg/kg), 3-5) ag 50, 100 and 150mg/kg 30 min before lps injectio...

background: memory impairment is a well-known effect of many benzodiazepine compounds which is mediated through their action on gamma-aminobutyric acid type a (gabaa) receptors. on the other hand, cannabinoids can affect learning and memory process through presynaptic modulation of the release of both excitatory glutamate and inhibitory gaba transmitters in brain regions involved in learning an...

Introduction: Ascorbic acid (AA) acts as an antioxidant in the Central nervous system (CNS) of the mammalians. It is released from the some nerve ending together with neurotransmitters. The results have shown that Ascorbic acid could affect learning as well as memory. In this study, we examined the effect of ICV injection of ascorbic acid on learning and memory by Morris water maze. Method: In...

introduction: olibanum improves memory in different models of learning. however, the effect of olibanum on models of alzheimer’s disease has been less studied. in the present study, the effect of olibanum on memory in normal rats and in a rat model of alzheimer disease induced by intracerebroventricular injections of streptozotocin was evaluated. methods: rats received an aqueous extract of oli...

introduction: learning and memory deficits in some diseases are new subjects of research. bupropion, as dopamine and noradrenaline reuptake inhibitor and an antidepressant agent, has been previously shown to affect learning and memory processes. this study was designed to test the effect of intra-hippocompal bupropion injection on active avoidance learning task in rats. methods: adult male wist...

increased level of stress has negative effects on cognitive functions. thus, it is necessary to identify appropriate strategies to prevent cognitive and motor performance decline. the aim of this research was to study the effect of immobilization stress on learning and memory and the protective role of physical activity in them. from male albino-wistar rats of pastor institute, 32 rats were ran...

Background and Objective: Based on the effect of chronic metabolic diseases including diabetes mellitus on the learning and memory, this study was designed to assess the usefulness of administration of salvialonic acid B on lessening of learning and memory deficits in streptozotocin (STZ)-diabetic rats. Materials and Methods: Male Wistar rats were allocated into control, salvialonic acid B-trea...

background: acoustic noise is one of the universal pollutants of modern society. although the high level of noise adverse effects on human hearing has been known for many years, non-auditory effects of noise such as effects on cognition, learning, memory and reading, especially on children, have been less considered. factors which have negative impact on these features can also have a negative ...