In previous communications (4, 5) we have reported that in animals with carcinoma, whether induced, transplanted, or spontaneous, there was an increase in serum lactic dehydrogenase (LDH) activity. A direct relationship was also demonstrated between LDH activity and tumor growth and regression. As the tumor grew, the LDH activity was progressively elevated, and, as the tumor regressed, LDH acti...

Prior epidemiologic research revealing cardioprotective effects of alcohol intake has systematically neglected lifetime exposure to alcohol, which may cause serious bias in conclusions regarding drinking and heart disease risk. Departing from use of an earlier interview schedule, the authors of the present 1996-2001 cohort study developed a self-administered Lifetime Drinking History questionna...

The previously cloned gene for L-(+)-lactate dehydrogenase (LDH) from Streptococcus mutans was mutagenized in vitro. An Escherichia coli transformant which expressed a thermolabile LDH activity was identified. The ldh(Ts) gene was introduced into S. mutans on a suicide vector to create a heterodiploid expressing both wild-type and thermolabile LDH activities. Self-recombinants which had only on...

OBJECTIVE Lactate dehydrogenase (LDH) anomaly is one of the macroenzymes. Macroenzymes are enzymes in serum that have formed high molecular mass complexes, either by self polymerisation or by association with other serum components. The aim of this study was to identify the properties of LDH anomaly and observe the changes from admission to discharge in a postburn patient with LDH anomaly in hi...

Aqueous miscible organic layered double hydroxides (AMO-LDHs) can act as organophilic inorganic flame retardant nanofillers for unmodified non-polar polymers. In this contribution, AMO [Mg3Al(OH)8](CO3)0.5·yH2O LDH-oxidized carbon nanotube (AMO-LDH-OCNT) hybrids are shown to perform better than the equivalent pure AMO-LDH. A synergistic effect between the AMO-LDH and OCNT was observed; this end...

OBJECTIVES The aim of this study is to determine the longest acceptable serum-clot contact time before centrifugation in lactate dehydrogenase and inorganic phosphorus analysis. MATERIALS AND METHODS The LDH and inorganic phosphorus serum levels from 103 adults were analyzed at three different storage times. The three measures were done immediately (T0), after a 2-h serum-clot contact (T2) an...

The objective of this study was to determine the activities lactate dehydrogenase (LDH), alkaline phosphatase (ALP), gamma-glutamyl transferase (GGT), aspartate aminotransferase (AST) and alanine (ALT) in milk blood lactating Holstein cows investigate their association with subclinical mastitis (SCM). This also aims evaluate impact SCM its severity based on California test (CMT) scores above me...

We have previously established the importance of a promoting vibration, a subpicosecond protein motion that propagates through a specific axis of residues, in the reaction coordinate of lactate dehydrogenase (LDH). To test the effect that perturbation of this motion would have on the enzymatic reaction, we employ transition path sampling to obtain transition path ensembles for four independent ...