IMPORTANCE Major depressive disorder (MDD) frequently emerges during adolescence and can lead to persistent illness, disability, and suicide. The maturational changes that take place in the brain during adolescence underscore the importance of examining neurobiological mechanisms during this time of early illness. However, neural mechanisms of depression in adolescents have been understudied. R...

Dermatological malignancy is the commonest form of cancer in the United Kingdom.1 Basal cell carcinoma accounts for approximately 80% of all non-melanocytic tumours, with a similar percentage affecting the head and neck.2 Tumour growth patterns are variable in this condition,3 with most interest focusing on 'rodent ulcers' affecting the head and neck. Little is known about the inherent biologic...

Rosen, Castleman, and Liebow (1958) defined a " new " syndrome which they called pulmonary alveolar proteinosis, though it is surprising that the malady should have escaped the notice of competent workers of the past. They based their observations on a series of 27 cases (25 of which had been referred to them for opinion), 24 from the United States, and one each from Canada, Great Britain, and ...

jHauwolfia serpentina has been known as a medicinal plant in India for a long time but its use in the treatment of hypertension is of comparatively recent origin. The dried root contains 1 per cent of total alkaloids besides resin, starch, potassium carbonate, phosphate, silicate and traces of iron and manganese (Sen and Bose, 1931). Siddiqui and Siddiqui (1931) found two groups of alkaloids an...

Kuru, a chronic subacute heredofamilial disease of man in the eastern highlands of New Guinea, and Creutzfeldt-Jakob disease, one of the presenile dementias which occurs sporadically and in familial patterns in man throughout the world, are caused by infectious agents which are experimentally transmissible from man to chimpanzees and several Both kuru and Creutzfeldt-Jakob disease are associate...

CRMO is an autoinflammatory disease of children and young adults, characterized by the insidious onset of local pain and swelling in affected bone and fever. The bone lesions are radiologically characterized as multiple luciens surrounded by defined zones of patchy but dense sclerosis, cortical tickening from periosteal new bone formation, and increased bone size with different bones involved. ...

Amebiasis is typically an infection of the colon by the protozoan, Endamoeba histolytica. It may be acute or chronic and presents a varied clinical course. The most frequent symptom is diarrhea with small amounts of blood-streaked mucus, but stubborn constipation is not unusual. Often, constipation may alternate with diarrhea accompanied by tenesmus, lassitude, and a generalized vague abdominal...

Precocious puberty is considered to be present when gonadal function, which is adult in type and degree, is accompanied by secondary sex development, in the male or female, some years before this would normally be expected (Simpson, 1959). Seckel (1946) regarded genital maturation as precocious when it became apparent in boys before the age of 10 years and in girls before the age of 8 years. It...

Acute mountain sickness Many hundreds of studies of AMS over the past two centuries have examined the contributions of ventilation, pulmonary gas exchange and fluid balance to the pathophysiology of AMS. Unfortunately, the traditional paradigm that invoked these peripheral responses to acute hypobaric hypoxia to explain AMS failed to substantially advance our understanding. Therefore, this revi...

BACKGROUND Modern studies have shown that psoralen has a significant inhibitory effect on tumor growth in a variety of animals and humans. OBJECTIVE To obtain coumarin compounds - psoralen and isopsoralen - from traditional Chinese medicine Psoralea corylifolia L. using chromatographic techniques and isolation and purification methods, and to observe the transplanted tumor growth inhibitory e...