نتایج جستجو برای: lasb

تعداد نتایج: 140  

2016
Ramadan Hassan Mona I. Shaaban Fatma M. Abdel Bar Areej M. El-Mahdy Shadi Shokralla

Quorum sensing (QS) systems communicate bacterial population and stimulate microbial pathogenesis through signaling molecules. Inhibition of QS signals potentially suppresses microbial infections. Antimicrobial properties of Streptomyces have been extensively studied, however, less is known about quorum sensing inhibitory (QSI) activities of Streptomyces. This study explored the QSI potential o...

Journal: :Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017
YongTao Li JianRong Huang LanJuan Li LinSheng Liu

BACKGROUND/AIMS Pseudomonas aeruginosa (PA) is one of the major opportunistic pathogens which can cause chronic lung infection of cystic fibrosis (CF). The formation of PA biofilm promotes CF development and restricts the antimicrobial efficacies of current antibiotics. METHODS The antimicrobial effects of azithromycin (AZM) and berberine (BER) alone and in combination were evaluated using mi...

2018
Marc Simard Caroline Underhill Geoffrey L Hammond

Corticosteroid-binding globulin (CBG) is a plasma carrier of glucocorticoids. Human and rat CBGs have six N-glycosylation sites. Glycosylation of human CBG influences its steroid-binding activity, and there are N-glycosylation sites in the reactive center loops (RCLs) of human and rat CBGs. Proteolysis of the RCL of human CBG causes a structural change that disrupts steroid binding. We now show...

Journal: :Infection and immunity 2009
James J Mun Connie Tam David Kowbel Samuel Hawgood Mitchell J Barnett David J Evans Suzanne M J Fleiszig

Our previous studies showed that surfactant protein D (SP-D) is present in human tear fluid and that it can protect corneal epithelial cells against bacterial invasion. Here we developed a novel null-infection model to test the hypothesis that SP-D contributes to the clearance of viable Pseudomonas aeruginosa from the healthy ocular surface in vivo. Healthy corneas of Black Swiss mice were inoc...

Journal: :Infection and immunity 2013
Brandon M Childers Tricia A Van Laar Tao You Steven Clegg Kai P Leung

Biofilm formation and persistence are essential components for the continued survival of pathogens inside the host and constitute a major contributor to the development of chronic wounds with resistance to antimicrobial compounds. Understanding these processes is crucial for control of biofilm-mediated disease. Though chronic wound infections are often polymicrobial in nature, much of the resea...

2016
Viraj C. Gala Nithya R. John Ashok M. Bhagwat Ajit G. Datar Prashant S. Kharkar Krutika B. Desai

BACKGROUND & OBJECTIVES The pathogenicity of the nosocomial pathogens, Pseudomonas aeruginosa and Acinetobacter baumannii is regulated by their quorum sensing (QS) systems. The objective of the present study was to examine the effect of the cold ethyl acetate extract of Tinospora cordifolia stem on virulence and biofilm development in the wild type and clinical strains of P. aeruginosa and A. b...

2008
Gustavo A Medrano Alfredo de Micheli Pedro Iturralde

Septal necrosis + peripheral left blocks. Because of an extensive septal necrosis, the manifestation of the initial ventricular activation forces decreases in the precordial leads. With left bifascicular block (LASB + LPSB), the first ventricular activation forces become more evident and the electrical signs of septal necrosis can be concealed. In the presence of a trifascicular block, manifest...

ژورنال: یافته 2016

Background : Pseudomonas aeruginosa is an opportunistic pathogen and the cause of 10% to 15% of ‎nosocomial infections.Virulence genes of Pseudomonas aeruginosa is one of the most ‎aggressive mechanisms and the issue of medical opinion is important. The expression of many ‎genes is controlled and regulated in pathogenic bacteria Pseudomonas aeruginosa gene by a ‎system called Qu...

Journal: :Journal of medical microbiology 2016
Soha El-Shaer Mona Shaaban Rasha Barwa Ramadan Hassan

The spread of multidrug-resistant Pseudomonas aeruginosa isolates constitutes a serious clinical challenge. Bacterial efflux machinery is a crucial mechanism of resistance among P. aeruginosa. Efflux inhibitors such as phenylalanine arginyl β-naphthylamide (PAβN) promote the bacterial susceptibility to antimicrobial agents. The pathogenesis of P. aeruginosa is coordinated via quorum sensing (QS...

2013
Amélie Beury-Cirou Mélanie Tannières Corinne Minard Laurent Soulère Tsiry Rasamiravaka Robert H. Dodd Yves Queneau Yves Dessaux Catherine Guillou Olivier M. Vandeputte Denis Faure

N-acylhomoserine lactone (AHL)-mediated quorum-sensing (QS) regulates virulence functions in plant and animal pathogens such as Agrobacterium tumefaciens and Pseudomonas aeruginosa. A chemolibrary of more than 3500 compounds was screened using two bacterial AHL-biosensors to identify QS-inhibitors (QSIs). The purity and structure of 15 QSIs selected through this screening were verified using HP...

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