The throat is an ecological assemblage involved human cells and microbiota, and the colonizing bacteria are important factors in balancing this environment. However, this bacterial community profile has thus been poorly investigated. The purpose of this study was to investigate the microbial biology of the larynx and to analyze the throat biodiversity in laryngeal carcinoma patients compared to...

The treatment of advanced laryngeal cancer has undergone a paradigm shift in recent years, with an increase in chemoradiation for organ preservation and a decrease in primary surgery. This review will summarize the contemporary management of advanced laryngeal cancer and discuss treatment-related toxicity and strategies to improve outcomes. LEVEL OF EVIDENCE NA.

Cancer complicates approximately 0.1% of all pregnancies. Head and neck cancer during pregnancy is uncommon. Specifically, laryngeal in has only been previously reported 10 times.From a maternal outcome perspective, 60% cases recurrence-free survival. Patient should be counseled on the risk for potential disease recurrence after treatment delivery.Thus pregnant patients treated multidisciplinar...

BACKGROUND AND OBJECTIVES Studies investigating the association between glutathione S-transferase M1 (GSTM1) gene polymorphism and laryngeal cancer risk have reported conflicting results. The aim of the present study was to conduct a meta-analysis assessing the possible associations of GSTM1 gene polymorphism with laryngeal cancer risk. METHODS The relevant studies were identified through a s...

Upper gastrointestinal (GI) bleeding can be a rare manifestation of primary or metastatic tumor in the stomach. Tumors that commonly metastasize to stomach include breast, lung, and malignant melanoma. Laryngeal cancer usually metastasizes to the lung and cervical spine. We report the first case of upper GI bleed as a manifestation of laryngeal cancer in the stomach.

tuberculosis is a major health problem in iran and its laryngeal involvement is not uncommon. laryngeal tuberculosis is so infectious and delay in diagnosis and treatment could result spread of disease and causes divesting complications. we reviewed clinical and para-clinical characteristics of patients with laryngeal tuberculosis in iran. in a cross sectional study, patients with laryngeal tub...

The aim of this study was to explore the relationship between the expression of p53, p21 and Cdc2 in the early laryngeal cancer with negative pathological margins and its local recurrence. During 2004-2010, a total of 85 patients with early laryngeal cancer were selected in Tangshan Union Hospital, Hebei, China, and immunohistochemical method was used to detect the expression of p53, p21 and Cd...

Introduction For locally advanced-stage laryngeal and hypopharyngeal cancer, the total laryngectomy or laryngopharyngectomy can be an option for primary treatment. This is indicated when a partial resection not achievable while obtaining organ function preservation of its through radiotherapy possible.

In a previous trial, we found that combined 13-cis-retinoic acid, IFN-alpha, and alpha-tocopherol more effectively reversed advanced premalignant lesions of the larynx than of the oral cavity and that cyclin D1 (CD1) G/A870 single nucleotide polymorphism correlated with cancer risk. We conducted the present trial primarily to confirm the clinical activity of the combination in advanced laryngea...

OBJECTIVES To provide comprehensive temporal trend analysis of 5-year relative survival rates of laryngeal cancer using the Surveillance, Epidemiology, and End Results database; and to expand on prior reports by including inclusion of laryngeal tumor location, stage, age at diagnosis, treatment strategy, and histologic grade. DESIGN Retrospective cohort analysis using the Surveillance, Epidem...