نتایج جستجو برای: large granular lymphocyte lgl
تعداد نتایج: 1106700 فیلتر نتایج به سال:
AIMS To compare the polymerase chain reaction (PCR) assay with standard Southern blot (SB) hybridisation for the detection of clonal T cell receptor (TCR) gene rearrangements in large granular lymphocyte (LGL) proliferations; to evaluate the reliability and practicality of the methods for routine diagnostic use; and to determine the sensitivity of the PCR method. METHODS Blood lymphocytes wer...
The case is reported of a 45 year old woman with the rare leukaemia of natural killer cell large granular lymphocyte (NK/ LGL) type. Cytometric analysis of leukaemic blasts showed that they were positive for CD2, CD38, and CD56 antigens but negative for a series of antigens including CD3, CD7, CD16, and HLA-DR. Rearrangements of the beta T cell receptor, and heavy and kappa immunoglobulin genes...
Large Granular Lymphocytic Leukemia (LGLL), a rare lymphoproliferative disorder of T cell or Natural Killer cell (NK) origin is characterized by persistent immunodominant clones of CD3+ Cytotoxic T Lymphocyte (CTLs) or CD3NK cells. Dysregulated homeostasis of CTL and NK cells may be due to various pathogenic factors, including the recently identified somatic STAT3 mutations. Occurrence of sever...
Fani Papagiannouli1 and Bernard M. Mechler2,3,4 1Cell Networks–Cluster of Excellence, Centre for Organismal Studies (COS) and BIOQUANT Center, University of Heidelberg, Heidelberg, 2Department of Cell Biology, Institute of Physiology, 1st Faculty of Medicine, Charles University, Prague, 3Deutsches Krebsforschungszentrum, Heidelberg, 4VIT-University, Vellore, Tamil Nadu, 1,3Germany 2Czech Republ...
Large granular lymphocyte (LGL) 1 is a cell surface glycoprotein expressed on a subset (50%) of C57BL/6 natural killer (NK) cells. Immunoprecipitation experiments reveal that the LGL-1 protein exists as a disulfide-linked 40-kD homodimer. Functional studies of LGL-1 + cells indicate that selected H-2 d target cells are not lysed efficiently by these interleukin (IL)-2-cultured NK cells. These f...
The lymphoproliferative syndrome with large granular lymphocytes (LGL) is an heterogeneous disorder of unknown etiology. The analysis of T-cell receptor (TCR) genes rearrangements has shown that, in most cases, the disease is associated with clonal proliferation of CD8+CD57+ LGL. However, the putative neoplastic nature of these expansions remains questionable because clonal proliferations of CD...
Experiments will soon start taking data at CERN’s Large Hadron Collider (LHC) with high expectations for discovery of new physics phenomena. Indeed, the LHC’s unprecedented center-of-mass energy will allow the experiments to probe an energy regime where the standard model is known to break down. In this article, the experiments’ capability to observe new resonances in various channels is reviewed.
Mature Large Granular lymphocytes (LGL) disorders include a spectrum of conditions, ranging from polyclonal to clonal indolent and/or overt leukemic LGL proliferations. Most cases are represented by clonal expansions of TCRα/β+ LGL displaying a CD8+ phenotype with expression of cytotoxic T-cell antigens (CD57, CD16, TIA-1, perforin and granzyme B). Proliferations of CD3-CD16+ NK cells with a re...
نمودار تعداد نتایج جستجو در هر سال
با کلیک روی نمودار نتایج را به سال انتشار فیلتر کنید