Abstract Background Barrier disruption leading to impaired intestinal permeability in Crohn’s Disease (CD) has been associated with various processes, including (pro-inflammatory) cytokine production, mucus production and altered tight junction protein expression. A recent study showed that healthy first-degree relatives of CD patients had abnormal which was gut microbiome composition. We have ...

Neomycin and lactulose are thought to exert their influence on hepatic coma exclusively by interfering with the bacterial flora, but our results suggest a potential additional effect, namely interference with glutamine-dependent non-bacterial ammonia production.9 This glutamine-dependent ammonia production may exceed by far the bacterial ammonia production. We suggest that the mechanism of acti...

The effects of a chronic load of nonabsorbable sugars on intracolonic bacterial metabolism of carbohydrates and on H2 breath excretion are disputed. However, most of the discussion relies on indirect evidence or on results of in vitro studies. Thus, we attempted to assess directly and in vivo the effects on intracolonic metabolism of lactulose of a chronic oral load of this nonabsorbable disacc...

Objective. To report an unusual cause of coma in an adult. Design. Case report. Setting. University teaching hospital. Patient. A previously healthy 53-year-old man initially presented with altered mental status and progressed to coma. He was found to be substantially hyperammonemic and did not improve with lactulose therapy and continuous venovenous hemodialysis. Results. Biochemical testing r...

Using a pH-sensitive radiotelemetering device the effect of lactulose on luminal pH in the ileum, colon, and rectum has been compared with that of two other laxative agents. Lactulose produced marked acidification of proximal colonic contents but this effect was not consistently maintained into the distal colon. Sodium sulphate acidified distal rather than proximal colonic contents. However, fo...

The lactulose/L-rhamnose urinary excretion ratio during continued infusion of milks containing both sugars was used as an index of the permeability of the neonatal bowel to large and small molecules. Healthy infants of gestational age 31-36 weeks proved to have a period of enhanced permeability to lactulose during the first week of life, the lactulose/L-rhamnose excretion ratio being significan...

The functional integrity of the small bowel is impaired in coeliac disease. Intestinal permeability, as measured by the sugar absorption test probably reflects this phenomenon. In the sugar absorption test a solution of lactulose and mannitol was given to the fasting patient and the lactulose/mannitol ratio measured in urine collected over a period of five hours. The sugar absorption test was p...

Aim: This study aims to describe the prescribing pattern of lactulose in outpatient setting a public hospital.
 Methodology: is cross-sectional that was conducted Alkharj city. Prescription data were collected retrospectively from electronic medical records Results: A total 113 patients received hospital. Most them males (66.37%). Approximately 24% aged between 30-39 years and about 20.35%...

Despite steady progress in therapeutics of liver disease, portal systemic encephalopathy remains to be a great challenge for clinicians because of the heterogeneity of neuropsychiatric symptoms, multiple risk factors and complexity on achieving a sustained response. We aimed to evaluate the efficacy of L-Ornithin, L-Aspartate versus lactulose in Mexican patients with hyperammonemic hepatic ence...

Introduction.Chronic kidney disease (CKD) is a major public health problem that often goes unrecognized until late-stage disease.Patients with chronic kidney disease face with uremic toxins and hyperkalemia. Also fluid overload in CKD patients is associated with rapid decline in kidney function.Lactulose is a hyper osmotic agent and as a prebioticplays an important role in regulating serum urea...