Many compound screening collections are populated by members that possess a low degree of structural complexity. In an effort to generate compounds that are both complex and diverse, we have developed a strategy that uses natural products as a starting point for complex molecule synthesis. Herein we apply this complexity-to-diversity approach to abietic acid, an abundant natural product used co...

BACKGROUND Onychomycosis is common, accounting for up to 50% of all nail disorders. Toenail onychomycosis can cause nail deformity, embarrassment, pain and walking difficulties. Some populations, such as individuals with diabetes, are at higher risk for developing secondary complications such as infections. Treatment takes many months and therapeutic choices can increase clinical effectiveness,...

The issues of digital preservation of shapes and internal structures of historical and cultural objects are discussed. An overview of existing approaches to computer modeling of shapes is presented and corresponding problems are considered. We propose a digital preservation paradigm quite different from the currently popular "scan and mesh" approach yielding visible surface models. Our approach...

Evaluation of occupational exposure to solvent vapours in the production of paints and lacquers is presented. The measurements were carried out in 5 paint and lacquer producing plants of the varied level of technical and technological advancement. Evaluation of exposure was based on determination of all substances identified in the work environment. Analysis was performed by gas chromatography ...

Japanese lacquerware has been used from long ago in Japanese daily life. Makie is a famous surface decoration technique using metallic powders, color pigments, and lacquer. We propose a method for real-time rendering of Makie. The optical properties of the Makie surface is represented using Bidirectional Reflectance Distribution Function (BRDF). Sphere environment maps are generated for the rea...