Night vision was tested electroretinographically and psychophysically in a vitamin A deficient patient before and after therapy. Vitamin A deficiency resulted from malabsorption due to a jeujunoileal bypass operation. Before therapy the patient had severely reduced cone and rod function. After the reversal operation, accompanied by 5 injections of a total of 500,000 units of vitamin A, complete...

Dark-adapted static perimetric fields and rod full-field electroretinograms (ERGs) were measured in normal subjects and 15 patients with retinitis pigmentosa. Psychophysical thresholds for short-wavelength stimuli were obtained from 76 locations across the retina on a modified Octopus 201 perimeter; threshold differences to short- and long-wavelength stimuli were used to determine whether rods ...

PURPOSE Misfolding mutations in rod opsin are a major cause of the inherited blindness retinitis pigmentosa. Therefore, understanding the role of molecular chaperones in facilitating rod opsin biogenesis and the response to mutant rod opsin is important for retinal disease and fundamental retinal cell biology. A recent report has shown that Drosophila rhodopsin Rh1 requires calnexin (Cnx) for i...

PURPOSE Although rod photoreceptors are initially affected in retinitis pigmentosa (RP), the full-field of rod vision is not routinely characterized due to the unavailability of commercial devices detecting rod sensitivity. The purpose of this study was to quantify rod-mediated vision in the peripheral field from patients with RP using a new commercially available perimeter. METHODS Participa...

STUDY DESIGN Retrospective case series of one institute database. OBJECTIVE To investigate the differences in the metallic strength of rods used for implant failure in the dual growing rod technique and evaluate clinical outcomes. SUMMARY OF BACKGROUND DATA The dual growing rod technique in which implanted rods extend with the growth of the spine is a useful treatment for early onset scolio...

Anatomical and electrophysiological techniques were combined to study the morphology, synaptic connections, and response properties of two neurons in the rod pathway of the rabbit retina: the rod bipolar cell and the narrow-field, bistratified (NFB) amacrine cell. Rod bipolars receive synaptic input from rod cells in the outer plexiform layer (OPL), where their dendrites end as central elements...

A dominant form of human congenital nightblindness is caused by a gly90-->asp (G90D) mutation in rhodopsin. G90D has been shown to activate the phototransduction cascade in the absence of light in vitro. Such constitutive activity of G90D rhodopsin in vivo would desensitize rod photoreceptors and lead to nightblindness. In contrast, other rhodopsin mutations typically give rise to nightblindnes...

A method combined the self-consistent field theory (SCFT) for the rigid rod with the Helfrich curvature elasticity theory for the vesicle has been developed for studying the shape of vesicles anchored by rigid rod. Both the deformation of the vesicle and the density distribution of rod segments can be obtained. Because of the vesicle's impenetrability for the rod segments and the decrease of th...

The organization of the rod spherule and of the horizontal cell axon terminals within the invagination of the rod spherule in the human retina was examined in serial sections by electron microscopy. Twenty-one rod spherules were reconstructed in this study. Axon terminal processes of type I horizontal cells consistently make one or two small punctate synapses onto each rod spherule within the i...