Ankle-Foot Orthoses (AFOs) are commonly prescribed to promote gait in children with cerebral palsy (CP). The AFO prescription process is however largely dependent on clinical experience, resulting in confusing results regarding treatment efficacy. To maximize efficacy, the AFO's mechanical properties should be tuned to the patient's underlying impairments. This study aimed to investigate whethe...

Cartesian sti ness is usually described by a 6 6 matrix which is vital in the study of rigid body grasping by multiple robot ngers. In this thesis, a closed form expression is derived for evaluating the grasped object sti ness based on the contact geometry and sti ness properties of individual robot ngers. The kinematics of manipulation by elastic ngers is also developed which describes the in ...

This paper proposes a new bilateral control scheme to ensure both transparency and robust stability under unknown constant time delay in stiff environment. Furthermore, this method guaranties suitable performance and robust stability when transition occurs between soft and stiff environments. This framework is composed of an adaptive sliding mode controller and an adaptive impedance controller,...

BACKGROUND:The impact of tires on a deformable ground surface determines not only the ability vehicle to move, but also pressure through contact patch geometric characteristics. The soil is normalized and limited by conditions for preservation its agrophysical properties. Therefore, when creating vehicles various purposes their movement or trailers surfaces, it required calculate in design proc...

The Chromosome Region of Maintenance 1 (CRM1) protein mediates nuclear export of hundreds of proteins through recognition of their nuclear export signals (NESs), which are highly variable in sequence and structure. The plasticity of the CRM1-NES interaction is not well understood, as there are many NES sequences that seem incompatible with structures of the NES-bound CRM1 groove. Crystal struct...

Applying the method from recently developed fluctuation theorems to the stochastic dynamics of single macromolecules in ambient fluid at constant temperature, we establish two Jarzynski-type equalities: (1) between the log-mean-exponential (LME) of the irreversible heat dissiption of a driven molecule in nonequilibrium steady-state (NESS) and ln P(ness)(x) and (2) between the LME of the work do...

We compiled >200 nuclear export signal (NES)-containing CRM1 cargoes in a database named NESdb. We analyzed the sequences and three-dimensional structures of natural, experimentally identified NESs and of false-positive NESs that were generated from the database in order to identify properties that might distinguish the two groups of sequences. Analyses of amino acid frequencies, sequence logos...

The human norepinephrine transporter (NET) is implicated in many neurological disorders and is a target of tricyclic antidepressants and nisoxetine (NX). We used molecular docking simulations to guide the identification of residues likely to affect substrate transport and ligand interactions at NET. Mutations to alanine identified a hydrophobic pocket in the extracellular cavity of NET, compris...

In the theory of algebraic group actions on affine varieties, the concept of a Kempf– Ness set is used to replace the categorical quotient by the quotient with respect to a maximal compact subgroup. Using recent achievements of “toric topology,” we show that an appropriate notion of a Kempf–Ness set exists for a class of algebraic torus actions on quasiaffine varieties (coordinate subspace arra...