With the advent of novel mass spectrometry techniques such as Orbitrap MS, it is possible to determine the exact molecular formula of an unknown molecule solely from its isotope pattern. But for protein mass spectrometry, one is facing the problem that many peptides have exactly the same molecular formula even when ignoring the order of amino acids. In this work, we present an efficient method ...

In this paper we study and solve two different variants of static knapsack problems with random weights: The stochastic knapsack problem with simple recourse as well as the stochastic knapsack problem with probabilistic constraint. Special interest is given to the corresponding continuous problems and three different problem solving methods are presented. The resolution of the continuous proble...

We study the convex hull of the feasible set of the semi-continuous knapsack problem, in which the variables belong to the union of two intervals. Besides being important in its own right, the semi-continuous knapsack problem arises in a number of other contexts, e.g. it is a relaxation of general mixed-integer programming. We show how strong inequalities valid for the semi-continuous knapsack ...

The multidimensional knapsack problem (MKP) is a classic in combinatorial optimisation. Several authors have proposed to use surrogate relaxation compute upper bounds for the MKP. In their papers, dual solved heuristically. We show that, using modern simplex solver as subroutine, one can solve exactly reasonable computing times. On other hand, resulting bound tends be strong only relatively sma...

where the pairs (I+$, Xi) 2 0 are assumed to be independent draws from a common . . . . . joint distribution Fwx. If we think of the pairs (w,Xi) as the weights and values, respectively, of a collection of n objects, then this problem can be thought of as finding the collection of objects of maximum value which will fit in a “knapsack” with weight capacity 1. Our main result, Theorem 2.4, compu...

This paper is concerned with a variation of the multiple knapsack problem (MKP) [5, 6], where we are given a set of n items N = {1, 2, . . . , n} to be packed into m possible knapsacks M = {1, 2, . . . ,m}. As in ordinary MKP, by w j and p j we denote the weight and profit of item j ∈ N respectively, and the capacity of knapsack i ∈ M is ci. However, a fixed cost fi is imposed if we use knapsac...