نتایج جستجو برای: ki67

تعداد نتایج: 4147  

2017
Aranzazu Fernand ez-Martinez Tomás Pascual Giuseppe Perrone Serafin Morales Juan de la Haba Milagros González-Rivera Patricia Galván Francesca Zalfa Michela Amato Lucia Gonzalez Miquel Prats Federico Rojo Luis Manso Laia Paré Immaculada Alonso Joan Albanell Ana Vivancos Antonio González Judit Matito Sonia González Pedro Fernandez Barbara Adamo Montserrat Muñoz Margarita Viladot Carme Font Francisco Aya Maria Vidal Rosalía Caballero Eva Carrasco Vittorio Altomare Giuseppe Tonini Aleix Prat Miguel Martin

PAM50/Prosigna gene expression-based assay identifies three categorical risk of relapse groups (ROR-low, ROR-intermediate and ROR-high) in post-menopausal patients with estrogen receptor estrogen receptor-positive (ER+)/ HER2-negative (HER2-) early breast cancer. Low risk patients might not need adjuvant chemotherapy since their risk of distant relapse at 10-years is below 10% with endocrine th...

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2013
Min Liu Jin - Song Li Dong - Ping Tian Bo Huang Seema Rosqvist Min Su

has high incidence and poor prognosis requiring early screening of high-risk populations. Minichromosome maintenance (MCM) proteins are used as diagnosticbiomarkers in many cancers but not validated for GCC. We evaluate MCM protein 2 (MCM2), comparing it with the validated markers Ki67 and PCNA. Methods: GCC and corresponding cardiac precancerous samples were immunostained with Ki67, MCM2 and P...

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2014
XINWEN ZHONG XIAOJIAO GUAN WENKE LIU LIN ZHANG

The purpose of the present study was to identify a potential biomarker that is more effective than those already available for the prognosis of non-small cell lung cancer (NSCLC) patients. The expression of never in mitosis gene A (NIMA)-related kinase 2 (NEK2), minichromosome maintenance complex component 7 (Mcm7) and Ki67 was evaluated in 270 NSCLC tissues using immunohistochemical and immuno...

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2016
Shiro NAKAMURA

Author investigated the cell infiltrative activity, cell growth and cell proliferative activity of flat type colorectal cancer. Tissue specimens were obtained by surgery. These specimens were examined in expression of CD44 for the evaluation of cell infiltrative activity and Ki67 for growing cell, and then double-staining for AgNORs and Ki67 was performed to evaluate proliferative activity in g...

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2017
Jihai Jin Dongxing Zheng Yujuan Liu

OBJECTIVE To investigate the expression of Topo IIα and Ki67 and its clinical significance. METHODS The clinical pathological data of one hundred and sixteen invasive breast cancer patients who were admitted into our hospital from July 2013 to December 2015 and underwent radical mastectomy were retrospectively analyzed. The expression of topoisomerase (Topo) IIα and Ki67 was detected using im...

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2012
Esther Dur'an Ri'ansares Arriazu

Fifty cases of breast carcinoma were investigated for Nm23, LPA1, Ki67 and p53 antigen expression, using immunohistochemical techniques. Correlation between markers was studied. Nm23 showed an inverse correlation with LPA1 and Ki67, and positive with p53. Nm23/LPA1presented significant (p<0.001) negative correlation with p53, but not difference were observed with Ki67. It can be concluded that:...

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Journal: :Bratislavske lekarske listy 2013
Senol E Paksoy I Tasdelen Adim S Balaban G Ozkaya S Tolunay

OBJECTIVE The aim of the present study was to investigate the possibility to predict the histopathological features of breast and metastatic lymph nodes and survey and prognosis of patients and likelihood of being a predictive factor for treatment by using Ki67 immunohistochemical stain. MATERIALS AND METHODS 95 patients who were admitted to Uludag University Medical Faculty, Department of Ge...

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2016
Mustapha Abubakar William J Howat Frances Daley Lila Zabaglo Leigh‐Anne McDuffus Fiona Blows Penny Coulson H Raza Ali Javier Benitez Roger Milne Herman Brenner Christa Stegmaier Arto Mannermaa Jenny Chang‐Claude Anja Rudolph Peter Sinn Fergus J Couch Rob A.E.M. Tollenaar Peter Devilee Jonine Figueroa Mark E Sherman Jolanta Lissowska Stephen Hewitt Diana Eccles Maartje J Hooning Antoinette Hollestelle John WM Martens Carolien HM van Deurzen kConFab Investigators Manjeet K Bolla Qin Wang Michael Jones Minouk Schoemaker Annegien Broeks Flora E van Leeuwen Laura Van't Veer Anthony J Swerdlow Nick Orr Mitch Dowsett Douglas Easton Marjanka K Schmidt Paul D Pharoah Montserrat Garcia‐Closas

Automated methods are needed to facilitate high-throughput and reproducible scoring of Ki67 and other markers in breast cancer tissue microarrays (TMAs) in large-scale studies. To address this need, we developed an automated protocol for Ki67 scoring and evaluated its performance in studies from the Breast Cancer Association Consortium. We utilized 166 TMAs containing 16,953 tumour cores repres...

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2015
James Olayiwola Adisa Ejike Chukwudi Egbujo Babangida Ibrahim Bukar Musa Jonathan Madukwe

INTRODUCTION Diagnosis of prostatic diseases with Immunohistochemistry still faces challenges because of the peculiar histology of the prostate and difference(s) in reactivity of Monoclonal antibodies (MoAb) to benign and malignant changes. METHODS Thirty (30) archived paraffin embedded tissue samples from primary prostate tumors (15 Benign Prostatic Hyperplasia (BPH) and 15 Cancer of the pro...

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2014
Quinci Romero Pär-Ola Bendahl Mårten Fernö Dorthe Grabau Signe Borgquist

BACKGROUND Ki67 is currently the proliferation biomarker of choice, with both prognostic and predictive value in breast cancer. A lack of consensus regarding Ki67 use in pre-analytical, analytical and post-analytical practice may hinder its formal acceptance in the clinical setting. METHODS One hundred breast cancer samples were stained for Ki67. A standard estimation of Ki67 using fixed deno...

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function paginate(evt) { url=/search_year_filter/ var term=document.getElementById("search_meta_data").dataset.term pg=parseInt(evt.target.text) var data={ "year":filter_year, "term":term, "pgn":pg } filtered_res=post_and_fetch(data,url) window.scrollTo(0,0); } function update_search_meta(search_meta) { meta_place=document.getElementById("search_meta_data") term=search_meta.term active_pgn=search_meta.pgn num_res=search_meta.num_res num_pages=search_meta.num_pages year=search_meta.year meta_place.dataset.term=term meta_place.dataset.page=active_pgn meta_place.dataset.num_res=num_res meta_place.dataset.num_pages=num_pages meta_place.dataset.year=year document.getElementById("num_result_place").innerHTML=num_res if (year !== "unfilter"){ document.getElementById("year_filter_label").style="display:inline;" document.getElementById("year_filter_place").innerHTML=year }else { document.getElementById("year_filter_label").style="display:none;" document.getElementById("year_filter_place").innerHTML="" } } function update_pagination() { search_meta_place=document.getElementById('search_meta_data') num_pages=search_meta_place.dataset.num_pages; active_pgn=parseInt(search_meta_place.dataset.page); document.getElementById("pgn-ul").innerHTML=""; pgn_html=""; for (i = 1; i <= num_pages; i++){ if (i===active_pgn){ actv="active" }else {actv=""} pgn_li="
  • " +i+ "
    • "; pgn_html+=pgn_li; } document.getElementById("pgn-ul").innerHTML=pgn_html var pgn_links = document.querySelectorAll('.mypgn'); pgn_links.forEach(function(pgn_link) { pgn_link.addEventListener('click', paginate) }) } function post_and_fetch(data,url) { showLoading() xhr = new XMLHttpRequest(); xhr.open('POST', url, true); xhr.setRequestHeader('Content-Type', 'application/json; charset=UTF-8'); xhr.onreadystatechange = function() { if (xhr.readyState === 4 && xhr.status === 200) { var resp = xhr.responseText; resp_json=JSON.parse(resp) resp_place = document.getElementById("search_result_div") resp_place.innerHTML = resp_json['results'] search_meta = resp_json['meta'] update_search_meta(search_meta) update_pagination() hideLoading() } }; xhr.send(JSON.stringify(data)); } function unfilter() { url=/search_year_filter/ var term=document.getElementById("search_meta_data").dataset.term var data={ "year":"unfilter", "term":term, "pgn":1 } filtered_res=post_and_fetch(data,url) } function deactivate_all_bars(){ var yrchart = document.querySelectorAll('.ct-bar'); yrchart.forEach(function(bar) { bar.dataset.active = false bar.style = "stroke:#71a3c5;" }) } year_chart.on("created", function() { var yrchart = document.querySelectorAll('.ct-bar'); yrchart.forEach(function(check) { check.addEventListener('click', checkIndex); }) }); function checkIndex(event) { var yrchart = document.querySelectorAll('.ct-bar'); var year_bar = event.target if (year_bar.dataset.active == "true") { unfilter_res = unfilter() year_bar.dataset.active = false year_bar.style = "stroke:#1d2b3699;" } else { deactivate_all_bars() year_bar.dataset.active = true year_bar.style = "stroke:#e56f6f;" filter_year = chart_data['labels'][Array.from(yrchart).indexOf(year_bar)] url=/search_year_filter/ var term=document.getElementById("search_meta_data").dataset.term var data={ "year":filter_year, "term":term, "pgn":1 } filtered_res=post_and_fetch(data,url) } } function showLoading() { document.getElementById("loading").style.display = "block"; setTimeout(hideLoading, 10000); // 10 seconds } function hideLoading() { document.getElementById("loading").style.display = "none"; } -->