objective(s):melatonin is known as an anti-inflammatory agent, and it has been proven to exert neuroprotection through inhibition of cell death (apoptosis) in several models of brain injury.secondary injury following the primary traumatic brain injury (tbi) results in glial cells activation, especially astrocytes. in fact, astrocyte activation causes the production of pro-inflammatory cytokines...

Background and objectives: Melissa officinalis (MO) has shown antioxidant and anti-inflammatory properties and is traditionally believed to have anti-hyperglycemic effects. This study aims to evaluate the protective effects of MO on streptozotocin (STZ) induced pancreatic damage and thereupon diabetes in rats. Methods: STZ (60 mg/kg) was injected intraperitoneally to the rats in order to induc...

A variant subline (KG-1a) of the human acute myelogenous leukemia (AML) cell line (KG-1) has been isolated. The cells retain the same constitutive markers as the parent line, including HLA antigens, isoenzymes, and karyotype. The cells from the subline are morphologically and histochemically undifferentiated blast cells, while the parent cells and several of its clones are at the myeloblast and...

Abstract Background Berberine (Ber) is a herbal alkaloid with pharmacological activity in general and high anticancer potency particular. However, due to its low bioavailability, the difficulty reaching target choosing right dose, there need improve approaches of Ber use therapy. In this study, Ber, noncovalently bound carbon nanostructure C 60 fullerene (C ) at various molar ratios components,...

Introduction and Objective: liver is an important body organ without which life is impossible. Cyclophosphamide is an alkylating agent widely used as an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. The present study aimed to find a suitable antioxidant and examine the effect of vitamin E and selenium on reducing the side effects of cyclophosphamide on liver as a vit...

Granulocyte/macrophage colony-stimulating factor (GM-CSF) and interleukin-3 (IL-3) each bind specifically to a small number of high-affinity receptors present on the surface of the cells of the acute myelogenous leukemia line, KG-1. Through chemical cross-linking of IL-3 and GM-CSF to KG-1 cells, we identified distinct binding proteins for each of these cytokines with approximate molecular mass...

In this paper, we establish some connections between the concept of an equivalence of categories and that of an equivalence in a bicategory. Its main result builds upon the observation that two closely related concepts, which could both play the role of an equivalence in a bicategory, turn out not to coincide. Two counterexamples are provided for that goal, and detailed proofs are given. In par...