Aims: The foremost aim of this study was to evaluate the 1:1 formed complex when mefenamic acid interacts with Cu2+, Zn2+, and EDTA4- metal at physiological condition, which provides a better understanding pharmacological studies. This research provided information on binding affinity selective metals. It helps preparative, structural, reactivity studies for multiple drug designs in pharmaceuti...

A series of phenoxybenzylidene aroylhydrazine derivatives were synthesized and their structureswere confirmed using FT-IR and 1H-NMR spectroscopy. Analgesic profiles of all compoundswere examined using abdominal constriction test (writhing test). Most of synthesized compoundsinduced significant reduction in the writhing response as compared with controls. The mostactive compounds exhibited an a...

Anthranylic acid derivatives are direct structural analogs of salicylic acid derivatives. They possess analgesic, anti-inflammatory, and antipyretic activity. They are similar to pyrazolones in terms of analgesic and antipyretic activity, yet they exceed the anti-inflammatory activity of salicylates. The mechanism of action of this series of nonsteroid, anti-inflammatory analgesics is not concl...

Patience who suffered from menstrual pain disease is generally prescribed the non-steroidal anti-inflammatory drug (NSAIDs). Monorrhagia or another blood disorder & some gynecological disorder, which impairs body function and acts as an economic burden. Due to respective use of ACE by oral route, it may cause GI complication such bleeding, pain, perforation, abdominal swelling. To decrease ...

A simple method is presented for the analysis of 13 pharmaceutical and pharmaceutical metabolite compounds in sewage effluents and surface waters. The pharmaceutical compounds were extracted using a genetic solid-phase extraction (SPE) procedure using Phenomenex Strata X as a stationary phase. Extracts were quantitatively analysed by four separate reversed-phase high-performance liquid chromato...