This essay introduces a new featured section, to be published in Small Axe annually, that explores the critical vocabulary of field Caribbean studies.

OBJECTIVE To analyze the effects of hyaluronidase and hirudoid treatment on drug extravasation in neonates. METHODS The medical records of 13 neonates with drug extravasation treated with hyaluronidase and hirudoid between August 1(st), 2010 and May 1(st), 2012 were analyzed retrospectively. The treatment procedure for drug extravasation adhered to the protocol in neonatal department. The inf...

BACKGROUND Hyaluronic acid (HA) preparations are the most commonly used injectable fillers in esthetic medicine. In contrast to other injectable fillers with hyaluronidase, there is a tool available to reduce unwanted depots of this filler. AIMS The aim of this paper is to give an overview on the present literature and in addition to give some recommendations for use based on the experience o...

OBJECTIVE To investigate whether hyaluronidase (Hyalase) is a useful and justified addition to haematoma block for pain relief. METHODS The study was a randomised double blind trial of 33 consecutive patients attending the accident and emergency department for manipulation of distal radius fracture under haematoma block. Control patients received 1% lignocaine; the treatment group received 1%...

Jaagsiekte sheep retrovirus (JSRV) uses hyaluronidase 2 (Hyal2) as a cell entry receptor. By making inactivating mutations to the catalytic residues of human Hyal2, we found that hyaluronidase activity was dispensable for its receptor function. The affinities of the JSRV envelope glycoprotein for Hyal2 and the Hyal2 mutant were similar, and hyaluronan did not block either high-affinity interact...

1. It has been shown that a number of proteolytic enzymes and snake venom, in relatively small amounts, and within a wide range of pH variation, will restore hyaluronidase activity after its inhibition by serum. 2. The known properties of the venom protease are found to be identical with those of Haas' "proinvasin I." It is concluded that the protease of the venom offers adequate explanation fo...

'l'hc mechanisms responsible for the invasivencss of malignant tumors remain largely unknown. One explanation proposed is that malignant tumors may form a spreading factor that breaks down the barriers in surrounding normal tissues and thus permits penetration of tumor cells (6). If it exists, such a spreading factor would probably be hyaluronidasc which hydrolyses the connective tissue constit...

INTRALESIONAL HYALURONIDASE WITH TRIAMCINOLONE FOR RECALCITRANT PRETIBIAL MYXEDEMA Abstract Pretibial myxedema resulting in progressively worsening cutaneous induration and expanding nodules can lead to pain, discomfort and functional impairment. Treatment of resistant lesions presents a special challenge whereby topical therapies are insufficient, and systemic therapies are met with poor toler...

It has been demonstrated that some strains of Aerobacter aerogenes and Achromobacter fischeri synthesized relatively large amounts of a mucopolysaccharide which was depolymerized by hyaluronidase (Warren, 1950, 1951). This synthesis is of special interest because the bacterial mucopolysaccharide (hyaluronic acid) depolymerized by hyaluronidase has been generally assumed to be limited to the cap...