The accuracy of the Precision Xceed® hand-held meter as an on-site method for measuring blood β-hydroxybutyric acid (BHBA) and glucose concentrations, for the diagnosis of pregnancy toxemia and ketosis in dry and lactating dairy sheep, was assessed. Five to eight hours after the start of the morning feed, blood was collected once from 193 clinically healthy sheep (143 dry and 50 lactating). BHB...

In 1936 we reported the occurrence of severe ketosis “immediately following hypoglycemic shock in insulin-treated diabetics, who for some time prior to the insulin shock were well under control on diets containing 120 to 250 gm. of carbohydrates with commensurate doses of insulin” (1). Since 1935, when we first observed this causal connection between hypoglycemia and ketosis, appreciation of th...

The effects of ketone body metabolism suggests that mild ketosis may offer therapeutic potential in a variety of different common and rare disease states. These inferences follow directly from the metabolic effects of ketosis and the higher inherent energy present in d-beta-hydroxybutyrate relative to pyruvate, the normal mitochondrial fuel produced by glycolysis leading to an increase in the D...

Received: Revised: Accepted: July 16, 2011 October 02, 2011 October 24, 2011

In 1936 we reported the occurrence of severe ketosis “immediately following hypoglycemic shock in insulin-treated diabetics, who for some time prior to the insulin shock were well under control on diets containing 120 to 250 gm. of carbohydrates with commensurate doses of insulin” (1). Since 1935, when we first observed this causal connection between hypoglycemia and ketosis, appreciation of th...

A series of experiments was performed during the induction of starvation ketosis and in the acute reversal of the ketotic state. In contrast to the predictions of two widely held theories of ketogenesis, control of acetoacetate production by the liver appeared to be unrelated to changes in fatty acid mobilization from the periphery, fatty acid oxidation, fatty acid synthesis, or the acetyl coen...

In this study, it was aimed to investigate the serum levels of ANGPTL4, FGF21, IL-1β, IL-6, SOD, MDA, and biochemical hematological parameters in cows with subclinical ketosis. The mean β-hydroxybutyric acid (BHB) level 1.37 ± 0.04 mmol/L 10 dairy aged 3-5 years that were <21 days postpartum diagnosed BHB 0.40 0.08 healthy same period age range. An increase AST (P<0.001) a decreas...